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Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling
Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this family is known to control the mitochondrial outer membrane permeabilization (MOMP): a central step in the mitochondrial pathway of...
Using approximate Bayesian computation to quantify cell-cell adhesion parameters in a cell migratory process
In this work we implement approximate Bayesian computational methods to improve the design of a wound-healing assay used to quantify cell-cell interactions. This is important as cell-cell interactions, such as adhesion and...
Cancer cell migration on straight, wavy, loop and grid microfibre patterns.
Duo Zhang, Yaqi Sheng, Nicholas Piano, Theresa Jakuszeit, Edward Jonathan Cozens, Lingqing Dong, Alexander K Buell, Andreas Pollet, Iek Man Lei, Wenyu Wang, Eugene Terentjev, Yan Yan Shery Huang
Jan 28, 2022
The invasion speed of cell migration models with realistic cell cycle time distributions
Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show...
Migration and maturation of Langerhans cells in skin transplants and explants
Larsen, C.P., Steinman, R.M., Witmer-Pack, M.D., Hankins, D.F., Morris, P.J., and Austyn, J.M. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 172: 1483-1493, 1990
Published by: The Rockefeller University Press
Reconciling transport models across scales
Diffusive transport is a universal phenomenon, throughout both biological and physical sciences, and models of diffusion are routinely used to interrogate diffusion-driven processes. However, most models neglect to take into...
Migration and maturation of langerhans cells in skin transplants and explants
The behavior of Langerhans cells (LC) has been examined after skin transplantation and in an organ culture system. Within 24 h (and even within 4 h of culture), LC in epidermal sheets from allografts, isografts, and explants...
Published by: Rockefeller University
Using approximate Bayesian computation to quantify cell-cell adhesion parameters in a cell migratory process
In this work we implement approximate Bayesian computational methods to improve the design of a wound-healing assay used to quantify cell-cell interactions. This is important as cell-cell interactions, such as adhesion and...
Variable species densities are induced by volume exclusion interactions upon domain growth.
In this work we study the effect of domain growth on spatial correlations in agent populations containing multiple species. This is important as heterogenous cell populations are ubiquitous during the embryonic development of...
Incorporating pushing in exclusion-process models of cell migration
The macroscale movement behavior of a wide range of isolated migrating cells has been well characterized experimentally. Recently, attention has turned to understanding the behavior of cells in crowded environments. In such...
Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma.
Maria M Caffarel, Anasuya Chattopadhyay, Angela M Araujo, Julien Bauer, Cinzia G Scarpini, Nicholas Coleman
Aug 19, 2020
Oncostatin M receptor (OSMR) is commonly over-expressed in advanced cervical squamous cell carcinoma (SCC), producing a significantly worse clinical outcome. Cervical SCC cells that over-express OSMR show enhanced responsiveness...
cell migration Fibronectin integrin-α5β1 invasion oncostatin M receptor squamous cell carcinoma tissue transglutaminase Blotting Western Carcinoma Squamous Cell Female Fibronectins Fluorescent Antibody Technique GTP-Binding Proteins Humans Immunohistochemistry Immunoprecipitation Integrin alpha5beta1 Microscopy Confocal Neoplasm Invasiveness Oligonucleotide Array Sequence Analysis Protein Glutamine gamma Glutamyltransferase 2 Real-Time Polymerase Chain Reaction Receptors Oncostatin M Signal Transduction Tissue Array Analysis Transglutaminases Up-Regulation Uterine Cervical Neoplasms
Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling
Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this family is known to control the mitochondrial outer membrane permeabilization (MOMP): a central step in the mitochondrial pathway of...
Focal Adhesion-Independent Cell Migration.
Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations...
Migratory Metrics of Wound Healing
Metastatic dissemination generates an aggressive disease facilitated by enhanced migratory and invasive properties. Experimental approaches employ several in vitro and in vivo assays toward quantification of these...
The discovery and maturation of peptide biologics targeting the small G protein Cdc42
George JN Tetley, Natasha P Murphy, Stephane Bonetto, Gabriela Ivanova-Berndt, Jefferson Revell, Helen R Mott, R Neil Cooley, Darerca Owen
Jan 23, 2020
Cdc42 GTPase Kras (KRAS) biologics Cancer cancer therapeutics cell migration Cell Proliferation Cell Signaling cyclic peptide Drug Discovery Nuclear Magnetic Resonance (NMR) peptide conformation Binding Sites Cell Movement Cell Proliferation Cell-Penetrating Peptides Drug Discovery GTP Phosphohydrolases Humans Molecular Structure Neoplasm Invasiveness Neoplasms Peptides Cyclic Signal Transduction cdc42 GTP-Binding Protein ras Proteins
Steering cell migration by alternating blebs and actin-rich protrusions.
Alba Diz-Muñoz, Pawel Romanczuk, Weimiao Yu, Martin Bergert, Kenzo Ivanovitch, Guillaume Salbreux, Carl-Philipp Heisenberg, Ewa K Paluch
Sep 05, 2019
Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.
Joseph HR Hetmanski, Henry de Belly, Ignacio Busnelli, Thomas Waring, Roshna V Nair, Vanesa Sokleva, Oana Dobre, Angus Cameron, Nils Gauthier, Christophe Lamaze, Joe Swift, Aránzazu Del Campo, Tobias Starborg, Tobias Zech, Jacky G Goetz, Ewa K Paluch, Jean-Marc Schwartz, Patrick T Caswell
Jul 02, 2020
In development, wound healing, and cancer metastasis, vertebrate cells move through 3D interstitial matrix, responding to chemical and physical guidance cues. Protrusion at the cell front has been extensively studied, but the...
RhoGTPase Caveolae cell invasion cell migration Cytoskeleton durotaxis Extracellular Matrix membrane tension Actin Cytoskeleton Actins Animals Caveolae Cell Line Tumor Cell Membrane Cell Movement Cell Polarity Cell Surface Extensions Cytoskeleton Cytosol Extracellular Matrix Humans Mice Protein Kinase C Pseudopodia Rats Signal Transduction rho-Associated Kinases rhoA GTP-Binding Protein
Variable species densities are induced by volume exclusion interactions upon domain growth.
In this work we study the effect of domain growth on spatial correlations in agent populations containing multiple species. This is important as heterogenous cell populations are ubiquitous during the embryonic development of...
NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 Integrin.
Abdullah AA Alghamdi, Christopher J Benwell, Samuel J Atkinson, Jordi Lambert, Robert T Johnson, Stephen D Robinson
Jul 17, 2020
Angiogenesis relies on the ability of endothelial cells (ECs) to migrate over the extracellular matrix via integrin receptors to respond to an angiogenic stimulus. Of the two neuropilin (NRP) orthologs to be identified, both...
The invasion speed of cell migration models with realistic cell cycle time distributions
Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show...
Inference of cell-cell interactions from population density characteristics and cell trajectories on static and growing domains
A key feature of cell migration is how cell movement is affected by cell-cell interactions. Furthermore, many cell migratory processes such as neural crest stem cell migration [1, 2] occur on growing domains or in the presence...
Reconciling transport models across scales
Diffusive transport is a universal phenomenon, throughout both biological and physical sciences, and models of diffusion are routinely used to interrogate diffusion-driven processes. However, most models neglect to take into...
Specialized role of migratory dendritic cells in peripheral tolerance induction
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with tissue self antigens....
CD8 antigen langerin cell migration dendritic cell molecularly targeted therapy Langerhans Cells regulatory T lymphocyte
Published by: Rockefeller University
Pulling in models of cell migration
There are numerous biological scenarios in which populations of cells migrate in crowded environments. Typical examples include wound healing, cancer growth and embryo development. In these crowded environments cells are able to...
Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods.
Blebs and pseudopods can both power cell migration, with blebs often favored in tissues, where cells encounter increased mechanical resistance. To investigate how migrating cells detect and respond to mechanical forces, we used...
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