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Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells.
Emily Welby, Jorn Lakowski, Valentina Di Foggia, Dimitri Budinger, Anai Gonzalez-Cordero, Aaron TL Lun, Michael Epstein, Aara Patel, Elisa Cuevas, Kamil Kruczek, Arifa Naeem, Federico Minneci, Mike Hubank, David T Jones, John C Marioni, Robin R Ali, Jane C Sowden
May 23, 2018
Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retinal degeneration. Transplantation of stem cell-derived L/M-opsin cones, which form 90% of the human cone population, could provide...
cell surface markers cell transplantation therapy cone photoreceptor cells Human pluripotent stem cells Retinal Dystrophies retinal organoids Transcriptome Cell Differentiation Fetus Gene Expression Profiling Gene Expression Regulation Developmental Humans Induced Pluripotent Stem Cells Retina Retinal Cone Photoreceptor Cells Retinal Degeneration Rod Opsins Transcriptome