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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment
K Kirschner, T Chandra, V Kiselev, D Flores-Santa Cruz, IC Macaulay, HJ Park, J Li, DG Kent, R Kumar, DC Pask, TL Hamilton, M Hemberg, W Reik, AR Green
Jul 26, 2017
Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct...