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Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.
Paula A Coelho, Leah Bury, Marta N Shahbazi, Kifayathullah Liakath-Ali, Peri H Tate, Sam Wormald, Christopher J Hindley, Meritxell Huch, Joy Archer, William C Skarnes, Magdalena Zernicka-Goetz, David M Glover
Apr 15, 2019
To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4...
Polo-like-kinase-4 centrosome amplification Pancreas primary cilia Skin tumour development Animals Cell Proliferation Cells Cultured Centrioles Centrosome Cilia Filaggrin Proteins Hyperplasia Intermediate Filament Proteins Islets of Langerhans Membrane Proteins Mice Protein Precursors Protein Serine-Threonine Kinases