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Results: 35
Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation.
Marc Kermorgant, Nathalie Nasr, Marek Czosnyka, Dina N Arvanitis, Ophélie Hélissen, Jean-Michel Senard, Anne Pavy-Le Traon
Jul 17, 2020
It is well known that exposure to microgravity in astronauts leads to a plethora physiological responses such as headward fluid shift, body unloading, and cardiovascular deconditioning. When astronauts return to Earth, some...
Visualising the pressure-time burden of elevated intracranial pressure after severe traumatic brain injury
Joseph Donnelly, Fabian Güiza, Bart Depreitere, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski
Mar 10, 2021
Monitoring of Optimal Cerebral Perfusion Pressure in Traumatic Brain Injured Patients Using a Multi-Window Weighting Algorithm.
Xiuyun Liu, Natasha M Maurits, Marcel JH Aries, Marek Czosnyka, Ari Ercole, Joseph Donnelly, Danilo Cardim, Dong-Joo Kim, Celeste Dias, Manuel Cabeleira, Peter Smielewski
Nov 23, 2017
Methods to identify an autoregulation guided "optimal" cerebral perfusion pressure (CPPopt) for traumatic brain injury patients (TBI) have been reported through several studies. An important drawback of existing methodology is...
CPPopt TBI cerebral autoregulation multi-window algorithm pressure reactivity index Adult Algorithms Arterial Pressure Brain Injuries Traumatic Cerebrovascular Circulation Data Interpretation Statistical Female Glasgow Coma Scale Glasgow Outcome Scale Humans Intracranial Pressure Male Middle Aged Neurophysiological Monitoring Outcome Assessment Health Care Reproducibility of Results Retrospective Studies Young Adult
Relationship Between Baroreflex and Cerebral Autoregulation in Patients With Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage.
Agnieszka Uryga, Nathalie Nasr, Magdalena Kasprowicz, Karol Budohoski, Marek Sykora, Peter Smielewski, Małgorzata Burzyńska, Marek Czosnyka
Jan 28, 2022
Introduction: Common consequences following aneurysmal subarachnoid hemorrhage (aSAH) are cerebral vasospasm (CV), impaired cerebral autoregulation (CA), and disturbance in the autonomic nervous system, as indicated by lower...
Continuous cerebrovascular reactivity monitoring in moderate/severe traumatic brain injury
Frederick A Zeiler, Ari Ercole, Marek Czosnyka, Peter Smielewski, Gregory Hawryluk, Peter JA Hutchinson, David K Menon, Marcel Aries
Nov 27, 2019
Impaired cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI) is known to be associated with worse global outcome at 6-12 months. As technology has improved over the past decades, monitoring of...
Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury
Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Aug 07, 2020
BACKGROUND: After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed "optimal CPP" values based on...
Validation of non-invasive cerebrovascular pressure reactivity and pulse amplitude reactivity indices in traumatic brain injury
Leanne A. Calviello, András Czigler, Frederick A. Zeiler, Peter Smielewski, Marek Czosnyka
Jun 06, 2020
Can interhemispheric desynchronization of cerebral blood flow anticipate upcoming vasospasm in aneurysmal subarachnoid haemorrhage patients?
Michał M Placek, Peter Smielewski, Paweł Wachel, Karol P Budohoski, Marek Czosnyka, Magdalena Kasprowicz
Aug 08, 2019
BACKGROUND: Asymmetry of cerebral autoregulation (CA) was demonstrated in patients after aneurysmal subarachnoid haemorrhage (aSAH). A classical method for CA assessment requires simultaneous measurement of both arterial blood...
Aneurysmal subarachnoid haemorrhage cerebral autoregulation Cerebral vasospasm Interhemispheric asymmetry Multichannel matching pursuit phase shift time-frequency analysis transcranial Doppler ultrasonography Adult Cerebrovascular Circulation Homeostasis Humans Intracranial Aneurysm Predictive Value of Tests Prognosis Retrospective Studies Subarachnoid Hemorrhage Time Factors Ultrasonography Doppler Transcranial Vasospasm Intracranial
Statistical Signal Properties of the Pressure-Reactivity Index (PRx)
Objectives: The pressure-reactivity index (PRx) is defined in terms of the moving correlation
coefficient between intracranial pressure (ICP) and mean arterial pressure (MAP) and is a
measure of cerebral autoregulation ability....
Transcranial Doppler Based Cerebrovascular Reactivity Indices in Adult Traumatic Brain Injury
Background: Disruption in cerebrovascular reactivity following traumatic brain injury (TBI) is a known phenomenon that may hold prognostic value and clinical relevance. Ultimately, improved knowledge of this process and more...
Using the relationship between brain tissue regional saturation of oxygen and mean arterial pressure to determine the optimal mean arterial pressure in patients following cardiac arrest
Mypinder S Sekhon, Peter Smielewski, Tahara D Bhate, Penelope M Brasher, Denise Foster, David K Menon, Arun K Gupta, Marek Czosnyka, William R Henderson, Kenneth Gin, Graham Wong, Donald E Griesdale
Mar 19, 2019
INTRODUCTION: Prospectively assess cerebral autoregulation and optimal mean arterial pressure (MAPOPT) using the dynamic relationship between MAP and regional saturation of oxygen (rSO2) using near-infrared spectroscopy....
Validation of non-invasive cerebrovascular pressure reactivity and pulse amplitude reactivity indices in traumatic brain injury.
Leanne A Calviello, András Czigler, Frederick A Zeiler, Peter Smielewski, Marek Czosnyka
Dec 10, 2019
BACKGROUND: Two transcranial Doppler (TCD) estimators of cerebral arterial blood volume (CaBV) coexist: continuous outflow of arterial blood outside the cranium through a low-pulsatile venous system (continuous flow forward...
Cerebral arterial blood volume cerebral autoregulation Intracranial Pressure pressure reactivity index Transcranial Doppler Traumatic brain injury Adult Brain Injuries Traumatic Cerebrovascular Circulation Female Heart Rate Humans Intracranial Pressure Male Middle Aged Trauma Severity Indices Ultrasonography Doppler Transcranial
High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals
Amanjyot Singh Sainbhi, Logan Froese, Alwyn Gomez, Izzy Marquez, Fiorella Amenta, Carleen Batson, Kevin Y Stein, Frederick A Zeiler
Feb 09, 2023
Patient's Clinical Presentation and CPPopt Availability
Annalisa Liberti, Erta Beqiri, Ari Ercole, Manuel Cabeleira, Jeanette Tas, Frederick A Zeiler, Marek Czosnyka, Peter Smielewski, Marcel J Aries, CENTER-TBI High Resolution Substudy Participants and Investigators
Apr 17, 2020
BACKGROUND: The 'optimal' CPP (CPPopt) concept is based on the vascular pressure reactivity index (PRx). The feasibility and effectiveness of CPPopt guided therapy in severe traumatic brain injury (TBI) patients is currently...
Transcranial Doppler-derived indices of cerebrovascular haemodynamics are independent of depth and angle of insonation.
Michael Heckelmann, Ganeshwaran Shivapathasundram, Danilo Cardim, Peter Smielewski, Marek Czosnyka, Rita Gaio, Mark MP Sheridan, Matthias Jaeger
Nov 24, 2020
Continuous measurement of cerebral blood flow velocity (CBFV) of the middle cerebral artery (MCA) using transcranial Doppler (TCD) and arterial blood pressure (ABP) monitoring enables assessment of cerebrovascular haemodynamics....
cerebral autoregulation Mean index Monitoring Transcranial Doppler Ultrasonography Adult Aged Aged 80 and over Algorithms Blood Flow Velocity Cerebrovascular Circulation Female Hemodynamics Homeostasis Humans Image Interpretation Computer-Assisted Male Middle Aged Middle Cerebral Artery Ultrasonography Doppler Transcranial
Cerebral Autoregulation in Non-Brain Injured Patients
Yaroslava Longhitano, Francesca Iannuzzi, Giulia Bonatti, Christian Zanza, Antonio Messina, Daniel Godoy, Wojciech Dabrowski, Li Xiuyun, Marek Czosnyka, Paolo Pelosi, Rafael Badenes, Chiara Robba
Dec 15, 2021
Introduction: Cerebral autoregulation (CA) plays a fundamental role in the maintenance of adequate cerebral blood flow (CBF). CA monitoring, through direct and indirect techniques, may guide an appropriate therapeutic approach...
Transcranial Doppler Based Cerebrovascular Reactivity Indices in Adult Traumatic Brain Injury
Background: Disruption in cerebrovascular reactivity following traumatic brain injury (TBI) is a known phenomenon that may hold prognostic value and clinical relevance. Ultimately, improved knowledge of this process and more...
Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury
Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, Audny Anke, Ronny Beer, Bo-Michael Bellander, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Ana Stevanovic, Nina Sundström, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf
Jun 06, 2020
Abstract: Background: After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed “optimal CPP” values based...
Influence of mild-moderate hypocapnia on intracranial pressure slow waves activity in TBI
Erta Beqiri, Marek Czosnyka, Afroditi D. Lalou, Frederick A. Zeiler, Marta Fedriga, Luzius A. Steiner, Arturo Chieregato, Peter Smielewski
Jun 06, 2020
Validation of non-invasive cerebrovascular pressure reactivity and pulse amplitude reactivity indices in traumatic brain injury
Leanne A. Calviello, András Czigler, Frederick A. Zeiler, Peter Smielewski, Marek Czosnyka
Dec 22, 2020
Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury
Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, Audny Anke, Ronny Beer, Bo-Michael Bellander, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Ana Stevanovic, Nina Sundström, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf
May 26, 2021
Abstract: Background: After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed “optimal CPP” values based...
Wavelet pressure reactivity index
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Peter J Hutchinson, Xiao Hu, Peter Smielewski, Ken Brady
Nov 21, 2018
KEY POINTS: The brain is vulnerable to damage from too little or too much blood flow. A physiological mechanism termed cerebral autoregulation (CA) exists to maintain stable blood flow even if cerebral perfusion pressure (CPP)...
Novel index for predicting mortality during the first 24 hours after traumatic brain injury.
Hakseung Kim, Hack-Jin Lee, Young-Tak Kim, Yunsik Son, Peter Smielewski, Marek Czosnyka, Dong-Joo Kim
Feb 23, 2019
OBJECTIVE: Failure of cerebral autoregulation and subsequent hypoperfusion is common during the acute phase of traumatic brain injury (TBI). The cerebrovascular pressure-reactivity index (PRx) indirectly reflects cerebral...
ABP = arterial blood pressure AUC = area under the curve CBF = cerebral blood flow CPP = cerebral perfusion pressure CPPopt = optimal CPP GCS = Glasgow Coma Scale ICP = intracranial pressure NCCU = neurocritical care unit PRx = pressure-reactivity index ROC = receiver operating characteristic TBI = traumatic brain injury cerebral autoregulation cerebral perfusion pressure cerebrovascular reactivity dHP = duration of a severe hypoperfusion event dHP20 = dHP with an ICP threshold of 20 mm Hg dHP22 = dHP with an ICP threshold of 22 mm Hg Neurocritical care Traumatic brain injury ∆ CPP = optimal CPP − measured CPP Adult Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Female Glasgow Coma Scale Homeostasis Humans Intracranial Pressure Male Middle Aged Mortality Predictive Value of Tests Prospective Studies Retrospective Studies Time Factors Young Adult
Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury
Erta Beqiri, Peter Smielewski, Claude Guérin, Marek Czosnyka, Chiara Robba, Lars Bjertnæs, Shirin K Frisvold
Mar 20, 2023
acute brain injury cerebral autoregulation Intracranial Pressure Lung protective ventilation Positive end-expiratory pressure subarachnoid haemorrhage Transpulmonary pressure Traumatic brain injury Humans Respiratory Rate Carbon Dioxide Prospective Studies Cross-Over Studies Tidal Volume Brain Injuries Lung Injury Brain
Continuous Monitoring of Cerebral Autoregulation in Children Supported by Extracorporeal Membrane Oxygenation
Nicolas Joram, Erta Beqiri, Stefano Pezzato, Moscatelli Andrea, Chiara Robba, Jean-Michel Liet, Alexis Chenouard, Pierre Bourgoin, Marek Czosnyka, Pierre-Louis Léger, Peter Smielewski
Oct 15, 2020
OBJECTIVE: Cerebral autoregulation (CA) impairment may pose a risk factor for neurological complications among children supported by extracorporeal membrane oxygenation (ECMO). Our first objective was to investigate the...
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