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Monitoring Neurochemistry in Traumatic Brain Injury Patients Using Microdialysis Integrated with Biosensors
In a traumatically injured brain, the cerebral microdialysis technique allows continuous sampling of fluid from the brain’s extracellular space. The retrieved brain fluid contains useful metabolites that indicate the brain’s...
Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease.
Nasim Sheikh-Bahaei, Roido Manavaki, S Ahmad Sajjadi, Andrew N Priest, John T O'Brien, Jonathan H Gillard
Apr 11, 2019
BACKGROUND: Despite the well-documented relationship between lobar cerebral microbleeds (lCMB) and Alzheimer's disease (AD), there is limited knowledge about the role of lCMB in AD pathology. OBJECTIVE: To understand the nature...
Alzheimer’s disease FDG-PET PiB-PET cerebral metabolism cerebral perfusion lobar cerebral microbleeds susceptibility weighted imaging Aged Aged 80 and over Alzheimer Disease Amyloid beta-Peptides Brain cerebral hemorrhage Cognitive Dysfunction Female Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Male Positron-Emission Tomography
Focally perfused succinate potentiates brain metabolism in head injury patients.
Ibrahim Jalloh, Adel Helmy, Duncan J Howe, Richard J Shannon, Peter Grice, Andrew Mason, Clare N Gallagher, Matthew G Stovell, Susan van der Heide, Michael P Murphy, John D Pickard, David K Menon, T Adrian Carpenter, Peter J Hutchinson, Keri LH Carpenter
Oct 27, 2016
traumatic brain injury (human) cerebral metabolism Microdialysis nuclear magnetic resonance spectroscopy Succinate Adolescent Adult Biomarkers Brain Brain Chemistry Brain Injuries Traumatic Citric Acid Cycle Energy Metabolism Female Humans Male Microdialysis Middle Aged Nuclear Magnetic Resonance Biomolecular Perfusion Succinates Trauma Severity Indices Young Adult
Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction.
Abdelhakim Khellaf, Nuria Marco Garcia, Tamara Tajsic, Aftab Alam, Matthew G Stovell, Monica J Killen, Duncan J Howe, Mathew R Guilfoyle, Ibrahim Jalloh, Ivan Timofeev, Michael P Murphy, T Adrian Carpenter, David K Menon, Ari Ercole, Peter J Hutchinson, Keri LH Carpenter, Eric P Thelin, Adel Helmy
Jan 07, 2022
cerebral metabolism Microdialysis MITOCHONDRIAL DYSFUNCTION Succinate traumatic brain injury (human) Adult Brain Brain Injuries Traumatic Energy Metabolism Female Humans Intracranial Pressure Lactic Acid Male Microdialysis Middle Aged Mitochondria Nuclear Magnetic Resonance Biomolecular Pyruvic Acid Succinic Acid