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Performance of the ImmuView and BinaxNOW assays for the detection of urine and cerebrospinal fluid Streptococcus pneumoniae and Legionella pneumophila serogroup 1 antigen in patients with Legionnaires' disease or pneumococcal pneumonia and meningitis.
The performances of the ImmuView Streptococcus pneumoniae (Sp) and Legionella pneumophila (Lp) urinary antigen test were compared to that of the BinaxNOW Sp and Lp assays, using frozen urine from 166 patients with Legionnaires'...
Relevance of biomarkers across different neurodegenerative diseases
Alexander J. Ehrenberg, Ayesha Khatun, Emma Coomans, Matthew J. Betts, Federica Capraro, Elisabeth H. Thijssen, Konstantin Senkevich, Tehmina Bharucha, Mehrsa Jafarpour, Peter N. E. Young, William Jagust, Stephen F. Carter, Tammaryn Lashley, Lea T. Grinberg, Joana B. Pereira, Niklas Mattsson-Carlgren, Nicholas J. Ashton, Jörg Hanrieder, Henrik Zetterberg, Michael Schöll, Ross W. Paterson
Jun 06, 2020
Abstract: Background: The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and...
Cerebral autoregulation, cerebrospinal fluid outflow resistance, and outcome following cerebrospinal fluid diversion in normal pressure hydrocephalus.
Afroditi Despina Lalou, Marek Czosnyka, Joseph Donnelly, John D Pickard, FMedSci, Eva Nabbanja, Nicole C Keong, Matthew Garnett, Zofia H Czosnyka
Jun 12, 2018
OBJECTIVE: Normal pressure hydrocephalus is not simply the result of a disturbance in CSF circulation, but often includes cardiovascular comorbidity and abnormalities within the cerebral mantle. In this study, the authors have...
ABP = arterial blood pressure CBF = cerebral blood flow CPP = cerebral perfusion pressure ETV = endoscopic third ventriculostomy ICP = intracranial pressure MAP = mean ABP NPH = normal pressure hydrocephalus PRx PRx = pressure reactivity index RAP = cerebrospinal compensatory reserve index Rout = resistance to CSF outflow autoregulation cerebrospinal fluid fAMP = fundamental amplitude of ICP infusion test Normal pressure hydrocephalus pressure reactivity index Resistance to CSF outflow Aged Aged 80 and over blood pressure Cerebrovascular Circulation Cohort Studies Female Homeostasis Humans Hydrocephalus Normal Pressure Male Treatment Outcome Ventriculoperitoneal Shunt
Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly.
Afroditi D Lalou, Virginia Levrini, Marek Czosnyka, Laurent Gergelé, Matthew Garnett, Angelos Kolias, Peter J Hutchinson, Zofia Czosnyka
May 01, 2020
BACKGROUND:Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic...
cerebrospinal fluid Traumatic brain injury Hydrocephalus Ventriculomegaly CSF dynamics CSF infusion test
Published by: Fluids and barriers of the CNS
Viral Metagenomic Analysis of Cerebrospinal Fluid from Patients with Acute Central Nervous System Infections of Unknown Origin, Vietnam.
Nguyen To Anh, Le Nguyen Truc Nhu, Nguyen Thi Thu Hong, Tran My Phuc, Pham Thi Thanh Tam, Dang Thao Huong, Tran Tuan Anh, Xutao Deng, Ho Dang Trung Nghia, Tran Thua Nguyen, Nguyen Van Hung, Nguyen Dac Thuan, Pham Thi Hong Phuong, Nguyen Van Vinh Chau, Stephen Baker, Eric Delwart, Guy Thwaites, Le Van Tan, VIZIONS Consortium1
May 17, 2021
Central nervous system (CNS) infection is a serious neurologic condition, although the etiology remains unknown in >50% of patients. We used metagenomic next-generation sequencing to detect viruses in 204 cerebrospinal fluid...
Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly
Afroditi D. Lalou, Virginia Levrini, Marek Czosnyka, Laurent Gergelé, Matthew Garnett, Angelos Kolias, Peter J. Hutchinson, Zofia Czosnyka
Jun 06, 2020
Abstract: Background: Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic...
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes.
A Robust Protocol to Quantify Circulating Cancer Biomarker MicroRNAs
Reverse-transcriptase quantitative PCR (RT-qPCR) is a widely used method for quantifying microRNAs (miRNAs) in cells and tissues. However, the quantification of miRNAs in the circulation presents specific challenges. Here, we...
Skull base repair following endonasal pituitary and skull base tumour resection
Danyal Z Khan, Ahmad MS Ali, Chan Hee Koh, Neil L Dorward, Joan Grieve, Hugo Layard Horsfall, William Muirhead, Thomas Santarius, Wouter R Van Furth, Amir H Zamanipoor Najafabadi, Hani J Marcus
Sep 03, 2021
PURPOSE: Postoperative cerebrospinal fluid rhinorrhoea (CSFR) remains a frequent complication of endonasal approaches to pituitary and skull base tumours. Watertight skull base reconstruction is important in preventing CSFR. We...
CSF cerebrospinal fluid Cerebrospinal Fluid Leak Cerebrospinal fluid rhinorrhoea Endoscopic endonasal Endoscopic transsphenoidal surgery Skull base surgery Cerebrospinal Fluid Leak Cerebrospinal Fluid Rhinorrhea endoscopy Humans Postoperative Complications Retrospective Studies Skull Base Skull Base Neoplasms
Porohyperelastic anatomical models for hydrocephalus and idiopathic intracranial hypertension
Hakseung Kim, Byoung-Kyong Min, Dae-Hyeon Park, Stanley Hawi, Byung-Jo Kim, Zofia Czosnyka, Marek Czosnyka, Michael PF Sutcliffe, Dong-Joo Kim
Mar 03, 2015
Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson's Disease.
Ruwani S Wijeyekoon, Sarah F Moore, Krista Farrell, David P Breen, Roger A Barker, Caroline H Williams-Gray
Feb 19, 2020
Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes.
Edwin Jabbari, John Woodside, Tong Guo, Nadia K Magdalinou, Viorica Chelban, Dilan Athauda, Andrew J Lees, Thomas Foltynie, Henry Houlden, Alistair Church, Michele Tm Hu, James B Rowe, Henrik Zetterberg, Huw R Morris
Sep 06, 2019
OBJECTIVE: The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson's disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein biomarkers of APS using...
A method to isolate and cryopreserve cerebrospinal fluid mononuclear cells from external ventricular drains to investigate immunological processes in acute brain injuries.
The inflammatory response to acute brain injuries is a key contributor to subsequent outcome. The study of local central nervous system inflammatory responses is hindered by raised intracranial pressure precluding cerebrospinal...
Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats.
Freyja McClenahan, Christina Dimitriou, Christos Koutsakis, Dimitrios Dimitrakopoulos, Asterios Arampatzis, Paraskevi Kakouri, Michaela Kourla, Sofia Oikonomou, Evangelia Andreopoulou, Melina Patsonis, Danai-Kassandra Meri, Rana-Tahir Rasool, Robin Jm Franklin, Ilias Kazanis
Aug 25, 2021
Postnatal brain neural stem and progenitor cells (NSPCs) cluster in anatomically inaccessible stem cell niches, such as the subependymal zone (SEZ). Here, we describe a method for the isolation of NSPCs from live animals, which...
cerebrospinal fluid ependymal cell Liquid biopsy Neural Stem Cells Neuraminidase Neurogenesis oligodendrocyte progenitor cells Stem Cell Niche subependymal zone Ventricular-subventricular zone Animals Brain Cell Culture Techniques Cell Differentiation cerebrospinal fluid Corpus Callosum Humans Liquid biopsy Male Neural Stem Cells oligodendrocyte precursor cells Rats Rats Long-Evans Rats Sprague-Dawley Rats Wistar Stem Cell Niche
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Jul 25, 2020
Abstract: Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species...
Relevance of biomarkers across different neurodegenerative diseases
Alexander J. Ehrenberg, Ayesha Khatun, Emma Coomans, Matthew J. Betts, Federica Capraro, Elisabeth H. Thijssen, Konstantin Senkevich, Tehmina Bharucha, Mehrsa Jafarpour, Peter N. E. Young, William Jagust, Stephen F. Carter, Tammaryn Lashley, Lea T. Grinberg, Joana B. Pereira, Niklas Mattsson-Carlgren, Nicholas J. Ashton, Jörg Hanrieder, Henrik Zetterberg, Michael Schöll, Ross W. Paterson
Jun 10, 2020
Abstract: Background: The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and...
Florence R. Sabin, 1915
The Rockefeller University
Jan 01, 0001
Prof. Florence R. Sabin. The Method of Growth of the Lymphatic System
Lecture delivered December 18th, 1915
Published by: J.B. Lippincott Company
Fast imaging employing steady-state acquisition (FIESTA) MRI to investigate cerebrospinal fluid (CSF) within dural reflections of posterior fossa cranial nerves
Adolescent Adult Aged Aged 80 and over Cerebellar Neoplasms cerebrospinal fluid Child Child Preschool Cranial Nerves Ependymoma Female Humans Image Interpretation Computer-Assisted Infant Infratentorial Neoplasms Magnetic Resonance Imaging Male Medulloblastoma Middle Aged Radiotherapy Planning Computer-Assisted Reproducibility of Results Retrospective Studies
Cerebrospinal fluid dynamics in pediatric pseudotumor cerebri syndrome.
Afroditi-Despina Lalou, James S McTaggart, Zofia H Czosnyka, Matthew R Garnett, Deepa Krishnakumar, Marek Czosnyka
Jun 26, 2019
PURPOSE: There is a growing body of evidence highlighting the importance of comprehensive intracranial pressure (ICP) values in pseudotumor cerebri syndrome (PTCS). Due to the highly dynamic nature of ICP, several methods of ICP...
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.
Suman De, Daniel R Whiten, Francesco S Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I Sideris, Christopher G Taylor, Francesco A Aprile, Serge Muyldermans, Tuomas PJ Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Jul 24, 2019
Alzheimer’s disease cerebrospinal fluid Disease mechanism mild cognitive impairment protein aggregation Structure-function relation Super-resolution imaging Aged Alzheimer Disease Amyloid beta-Peptides Animals Biomarkers Camelids New World Cognitive Dysfunction Disease Progression Female Humans Male Protein Aggregates tau Proteins
Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly.
Afroditi D Lalou, Virginia Levrini, Marek Czosnyka, Laurent Gergelé, Matthew Garnett, Angelos Kolias, Peter J Hutchinson, Zofia Czosnyka
May 29, 2020
BACKGROUND: Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic...
Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.
Florent Mouliere, Richard Mair, Dineika Chandrananda, Francesco Marass, Christopher G Smith, Jing Su, James Morris, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld
Dec 06, 2018
Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell-free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used...
Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly
Afroditi D. Lalou, Virginia Levrini, Marek Czosnyka, Laurent Gergelé, Matthew Garnett, Angelos Kolias, Peter J. Hutchinson, Zofia Czosnyka
Mar 30, 2021
Abstract: Background: Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic...
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