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Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome.
Roberta Cagnetta, Christian K Frese, Toshiaki Shigeoka, Jeroen Krijgsveld, Christine E Holt
Oct 10, 2018
Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during neural wiring, but the full landscape of proteomic changes remains unknown due to limitations in axon sampling and sensitivity. By...
axon Axon guidance chemotropic response extrinsic cues growth cone local protein synthesis neural wiring pSILAC-SP3 Proteomics Retinal ganglion cell Animals Axons Brain-Derived Neurotrophic Factor Cells Cultured Embryo Nonmammalian Gene Expression Regulation Isotope Labeling Mass Spectrometry Netrin-1 Neuronal Outgrowth Proteome Proteomics Retinal Ganglion Cells Semaphorin-3A Xenopus laevis