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Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis.
Paola Dazzan, Julia M Lappin, Margaret Heslin, Kim Donoghue, Ben Lomas, Uli Reininghaus, Adanna Onyejiaka, Tim Croudace, Peter B Jones, Robin M Murray, Paul Fearon, Gillian A Doody, Craig Morgan
Nov 22, 2019
clinical outcome Functional outcome Psychosis Remission Schizophrenia Activities of Daily Living Adult Bipolar Disorder Female Follow-Up Studies Humans Logistic Models Male Outcome Assessment Health Care Psychiatric Status Rating Scales Psychotic Disorders Remission Induction Schizophrenia Schizophrenic Psychology United Kingdom Young Adult
p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.
Hiroyoshi Hattori, Rekin's Janky, Wilfried Nietfeld, Stein Aerts, M Madan Babu, Ashok R Venkitaraman
Feb 13, 2020
The human DNA damage response (DDR) triggers profound changes in gene expression, whose nature and regulation remain uncertain. Although certain micro-(mi)RNA species including miR34, miR-18, miR-16 and miR-143 have been...
AP-1 activator protein-1 DDR DNA damage response DNA damage response E2F1 transcription factor E2F1 FOXM1 forkhead box protein M1 NF-k B nuclear factor-k B NGS next-generation sequencing TF transcription factor TP53 tumour protein p53 clinical outcome computational analysis double stranded DNA breaks DSBs ionizing radiation IR miRNA micro-RNA micro-RNA misc RNA miscellaneous RNA next-generation sequencing p53 scRNA small cytoplasmic RNA snRNA small nuclear RNA snoRNA small nucleolar RNA tRNA transfer RNA Cell Line DNA Damage DNA Repair Gene Expression Regulation Gene Expression Regulation Neoplastic Genome Genome Human Humans MicroRNAs Neoplasms Organ Specificity Tumor Suppressor Protein p53
Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes
Emanuele F Osimo, Benjamin I Perry, Rudolf N Cardinal, Mary-Ellen Lynall, Jonathan Lewis, Arti Kudchadkar, Graham K Murray, Jesus Perez, Peter B Jones, Golam M Khandaker
Sep 15, 2020
Approximately one third of patients presenting with a first episode of psychosis need long-term support, but there is a limited understanding of the sociodemographic or biological factors that predict this outcome. We used...
Training in the use of intrapartum electronic fetal monitoring with cardiotocography
S Kelly, P Redmond, S King, C Oliver‐Williams, G Lamé, E Liberati, I Kuhn, C Winter, T Draycott, M Dixon‐Woods, J Burt
Jul 28, 2021
Background: Sub‐optimal classification, interpretation and response to intrapartum electronic fetal monitoring using cardiotocography are known problems. Training is often recommended as a solution, but there is lack of clarity...
Phosphorus spectroscopy in acute TBI demonstrates metabolic changes that relate to outcome in the presence of normal structural MRI.
Matthew G Stovell, Marius O Mada, T Adrian Carpenter, Jiun-Lin Yan, Mathew R Guilfoyle, Ibrahim Jalloh, Karen E Welsh, Adel Helmy, Duncan J Howe, Peter Grice, Andrew Mason, Susan Giorgi-Coll, Clare N Gallagher, Michael P Murphy, David K Menon, Peter J Hutchinson, Keri LH Carpenter
Nov 07, 2018