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Results: 11
HLA-DR/DQ molecular mismatch
Chris Wiebe, Vasilis Kosmoliaptsis, Denise Pochinco, Ian W Gibson, Julie Ho, Patricia E Birk, Aviva Goldberg, Martin Karpinski, Jamie Shaw, David N Rush, Peter W Nickerson
Sep 18, 2019
Alloimmune risk stratification in renal transplantation has lacked the necessary prognostic biomarkers to personalize recipient care or optimize clinical trials. HLA molecular mismatch improves precision compared to traditional...
clinical research/practice clinical trial design Histocompatibility kidney transplantation/nephrology major histocompatibility complex (MHC) rejection: T cell mediated (TCMR) rejection: antibody-mediated (ABMR) risk assessment/risk stratification Adult Biomarkers Child Epitopes Female HLA-DQ Antigens HLA-DR Antigens Histocompatibility Testing Humans Isoantigens Kidney Transplantation Male Middle Aged Models Molecular Prognosis Risk Factors Tissue Donors Transplantation Immunology
Observations on the ex situ perfusion of livers for transplantation.
Christopher JE Watson, Vasilis Kosmoliaptsis, Caitlin Pley, Lucy Randle, Corinna Fear, Keziah Crick, Alexander E Gimson, Michael Allison, Sara Upponi, Rebecca Brais, Ina Jochmans, Andrew J Butler
Apr 13, 2018
Normothermic ex situ liver perfusion might allow viability assessment of livers before transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 resulted in transplants. Hepatocellular damage...
clinical research/practice liver allograft function/dysfunction liver transplantation/hepatology metabolism/metabolite organ perfusion and preservation Adult Bile Ducts Biomarkers Female Follow-Up Studies Hepatocytes Humans Liver Transplantation Male Middle Aged Organ Preservation Perfusion Primary Graft Dysfunction Prognosis Reperfusion Injury Tissue Donors Tissue and Organ Procurement Young Adult
Donors With Immune Thrombocytopenia
PB Trotter, M Robb, D Summers, CJE Watson, M Clatworthy, JA Bradley, QA Hill, J Neuberger
Jan 11, 2017
clinical research/practice donors and donation: deceased health services and outcomes research hematology/oncology liver transplantation/hepatology organ acceptance organ transplantation in general registry/registry analysis risk assessment/risk stratification Adult Female Follow-Up Studies Graft Rejection Graft Survival Humans Liver Transplantation Male Middle Aged Postoperative Complications Prognosis Purpura Thrombocytopenic Idiopathic Registries Retrospective Studies Risk Factors Tissue Donors Tissue and Organ Procurement Transplant Recipients Young Adult
Machine Perfusion of Donor Livers for Transplantation
SA Karangwa, P Dutkowski, P Fontes, PJ Friend, JV Guarrera, JF Markmann, H Mergental, T Minor, C Quintini, M Selzner, K Uygun, CJ Watson, RJ Porte
Nov 17, 2017
With increasing demand for donor organs for transplantation, machine perfusion (MP) promises to be a beneficial alternative preservation method for donor livers, particularly those considered to be of suboptimal quality, also...
Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion
clinical research/practice kidney transplantation/nephrology organ acceptance organ perfusion and preservation Adult Aged Female Graft Rejection Humans Kidney Function Tests Kidney Transplantation Liver Male Organ Preservation Outcome Assessment Health Care Perfusion Tissue Donors Tissue Survival Tissue and Organ Procurement
First World Consensus Conference on pancreas transplantation
Ugo Boggi, Fabio Vistoli, Axel Andres, Helmut P Arbogast, Lionel Badet, Walter Baronti, Stephen T Bartlett, Enrico Benedetti, Julien Branchereau, George W Burke, Fanny Buron, Rossana Caldara, Massimo Cardillo, Daniel Casanova, Federica Cipriani, Matthew Cooper, Adamasco Cupisti, Josè Davide, Cinthia Drachenberg, Eelco JP de Koning, Giuseppe Maria Ettorre, Laureano Fernandez Cruz, Jonathan A Fridell, Peter J Friend, Lucrezia Furian, Osama A Gaber, Angelika C Gruessner, Rainer WG Gruessner, Jenny E Gunton, Duck-Jong Han, Sara Iacopi, Emanuele Federico Kauffmann, Dixon Kaufman, Takashi Kenmochi, Hussein A Khambalia, Quirino Lai, Robert M Langer, Paola Maffi, Lorella Marselli, Francesco Menichetti, Mario Miccoli, Shruti Mittal, Emmanuel Morelon, Niccolò Napoli, Flavia Neri, Jose Oberholzer, Jon S Odorico, Robert Öllinger, Gabriel Oniscu, Giuseppe Orlando, Monica Ortenzi, Marcelo Perosa, Vittorio Grazio Perrone, Henry Pleass, Robert R Redfield, Claudio Ricci, Paolo Rigotti, R Paul Robertson, Lainie F Ross, Massimo Rossi, Frantisek Saudek, Joseph R Scalea, Peter Schenker, Antonio Secchi, Carlo Socci, Donzilia Sousa Silva, Jean Paul Squifflet, Peter G Stock, Robert J Stratta, Chiara Terrenzio, Pablo Uva, Christopher JE Watson, Steven A White, Piero Marchetti, Raja Kandaswamy, Thierry Berney
Jul 30, 2021
Sensitization in transplantation
Anat R Tambur, Patricia Campbell, Anita S Chong, Sandy Feng, Mandy L Ford, Howard Gebel, Ronald G Gill, Garnett Kelsoe, Vasilis Kosmoliaptsis, Roslyn B Mannon, Michael Mengel, Elaine F Reed, Nicole M Valenzuela, Chris Wiebe, I Esme Dijke, Harold C Sullivan, Peter Nickerson
Jan 07, 2021
The purpose of the STAR 2019 Working Group was to build on findings from the initial STAR report to further clarify the expectations, limitations, perceptions, and utility of alloimmune assays that are currently in use or in...
Use of ex vivo normothermic machine perfusion after normothermic regional perfusion to salvage a poorly perfused DCD kidney.
Normothermic regional perfusion (NRP) and normothermic machine perfusion (NMP) have both been used in the procurement and conditioning of abdominal organs from donation after circulatory death donors with reported improved...
clinical research/practice donors and donation: donation after circulatory death (DCD) kidney transplantation/nephrology organ perfusion and preservation organ procurement organ procurement and allocation organ transplantation in general Aged DEATH Extracorporeal Circulation Humans Kidney Male Organ Preservation Perfusion Tissue Donors Tissue Survival Tissue and Organ Procurement
Pancreatic allograft thrombosis
A Hakeem, J Chen, S Iype, MR Clatworthy, CJE Watson, EM Godfrey, S Upponi, K Saeb-Parsy
Nov 30, 2017
Pancreatic allograft thrombosis (PAT) remains the leading cause of nonimmunologic graft failure. Here, we propose a new computed tomography (CT) grading system of PAT to identify risk factors for allograft loss and outline a...
clinical research/practice coagulation and hemostasis complication Graft Survival health services and outcomes research pancreas/simultaneous pancreas-kidney transplantation thrombosis and thromboembolism Adolescent Adult Algorithms Allografts Child Female Follow-Up Studies Graft Rejection Graft Survival Humans Male Middle Aged Pancreas Transplantation Postoperative Complications Prognosis Retrospective Studies Risk Factors Thrombosis Tomography X-Ray Computed Young Adult
In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival.
Christopher JE Watson, Fiona Hunt, Simon Messer, Ian Currie, Stephen Large, Andrew Sutherland, Keziah Crick, Stephen J Wigmore, Corrina Fear, Sorina Cornateanu, Lucy V Randle, John D Terrace, Sara Upponi, Rhiannon Taylor, Elisa Allen, Andrew J Butler, Gabriel C Oniscu
Jan 08, 2019
clinical research/practice donors and donation: donation after circulatory death (DCD) extracorporeal membrane oxygenation (ECMO) liver transplantation/hepatology surgical technique Adolescent Adult Aged Bile Duct Diseases Bile Ducts Child DEATH Delayed Graft Function Extracorporeal Circulation Female Graft Survival Humans Ischemia Liver Transplantation Male Middle Aged Organ Preservation Perfusion Retrospective Studies Temperature Tissue and Organ Harvesting Tissue and Organ Procurement Young Adult