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Results: 51
Managing uncertain recovery for patients nearing the end of life in hospital
J Koffman, E Yorganci, D Yi, W Gao, F Murtagh, A Pickles, S Barclay, H Johnson, R Wilson, L Sampson, J Droney, M Farquhar, T Prevost, CJ Evans
Aug 19, 2019
BACKGROUND: The AMBER (Assessment, Management, Best Practice, Engagement, Recovery Uncertain) care bundle is a complex intervention used in UK hospitals to support patients with uncertain recovery. However, it has yet to be...
AMBER care bundle feasibility study clinical trial clinical uncertainty complex intervention end-of-life care mixed methods Palliative Care Aged Aged 80 and over Cluster Analysis Feasibility Studies Female Humans Male Middle Aged Patient Care Bundles Patient Selection Prospective Studies Research Design Terminal Care uncertainty
Virtual Environment Rehabilitation for Patients with Motor Neglect Trial (VERMONT)
Elsje de Villiers, Thomas Stone, Nai-Wei Wang, Viswadeep Sarangi, Adar Pelah, Nicholas Shenker
Apr 07, 2021
BACKGROUND: Motor neglect occurs in patients with chronic pain conditions. Virtual environments (VE) help rehabilitation through biofeedback and improving motivation. AIM: To assess the feasibility of a VE for patients with...
MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
Robin B Brown, Daniel J Tozer, Laurence Loubière, Young T Hong, Tim D Fryer, Guy B Williams, Martin J Graves, Franklin I Aigbirhio, John T O'Brien, Hugh S Markus
Oct 10, 2022
BACKGROUND: Cerebral small vessel disease (SVD) is a common cause of stroke and cognitive impairment. Recent data has implicated neuroinflammation and increased blood-brain barrier (BBB) permeability in its pathogenesis, but...
Adaptive sample size modification in clinical trials
We consider sample size re-estimation in a clinical trial, in particular when there is a significant delay before the measurement of patient response. Mehta and Pocock have proposed methods in which sample size is increased when...
Unsupervised home use of an overnight closed-loop system over 3-4 weeks
H Thabit, D Elleri, L Leelarathna, JM Allen, A Lubina-Solomon, M Stadler, E Walkinshaw, A Iqbal, P Choudhary, ME Wilinska, KD Barnard, SR Heller, SA Amiel, ML Evans, DB Dunger, R Hovorka
Feb 17, 2015
clinical trial closed-loop insulin delivery glycaemic control type 1 diabetes Adolescent Adult Algorithms Blood Glucose Blood Glucose Self-Monitoring Cross-Over Studies Diabetes mellitus Type 1 Female Glycated Hemoglobin Humans Hypoglycemia Hypoglycemic Agents Insulin Insulin Infusion Systems Male Middle Aged Time Factors Treatment Outcome
Complement inhibition in ANCA vasculitis.
David Jayne
Feb 21, 2020
A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a...
ANCA C5a clinical trial complement Therapy Vasculitis Aniline Compounds Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Monoclonal Clinical Trials Phase II as Topic Complement C5a Complement Inactivating Agents Complement Pathway Alternative Humans Neutrophil Activation Nipecotic Acids
Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease.
Qui Tu Phan, Lam Khanh Phung, Khanh Huu Truong, Trieu Trung Huynh, Giang Thanh Phạm, Bich Ngọc Nguyen, Quyen Thanh Tran, Vuong Ngoc Thien Huynh, Tien Thi My Nguyen, Thoa Phan Kim Le, Nhan Nguyen Thanh Le, Saraswathy Sabanathan, H Rogier van Doorn, Tan Van Le, Toan Duc Nguyen, Laura Merson, Dung Thi Phuong Nguyen, Ronald Geskus, Hung Thanh Nguyen, Chau Van Vinh Nguyen, Bridget Wills
Aug 24, 2020
BACKGROUND: Brainstem encephalitis is a serious complication of hand foot and mouth disease (HFMD) in children. Autonomic nervous system (ANS) dysregulation and hypertension may occur, sometimes progressing to cardiopulmonary...
Autonomic nervous system dysregulation Brainstem encephalitis clinical trial Hand foot and mouth disease Hypertension Magnesium sulfate Animals Autonomic Nervous System Autonomic Nervous System Diseases Child Child Preschool Cohort Studies Disease Progression Double-Blind Method Female Hand Foot and Mouth Disease Hemodynamics Humans Infant Magnesium sulfate Male Placebos
Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes
This work was supported by the Wellcome Trust Translational Medicine and Therapeutics Programme [RJAG/076 to TJ], Cancer Research UK and the Cambridge Translational Medicine and Therapeutics Academic Clinical Fellowship...
Role of hyperpolarization-activated cyclic nucleotide-gated ion channels in neuropathic pain
Shannon A Bernard Healey, Ingrid Scholtes, Mark Abrahams, Peter A McNaughton, David K Menon, Michael C Lee
Nov 03, 2021
Alemtuzumab for refractory primary systemic vasculitis-a randomised controlled dose ranging clinical trial of efficacy and safety (ALEVIATE).
Seerapani Gopaluni, Rona Smith, Donna Goymer, Hugh Cahill, Elizabeth Broadhurst, Elizabeth Wallin, Mark McClure, Afzal Chaudhry, David Jayne
Apr 01, 2022
BACKGROUND: Primary systemic vasculitis (PSV) is a heterogeneous group of autoimmune conditions. There is an unmet need for alternative therapies that lead to sustained remission in patients with refractory disease. Alemtuzumab...
A novel nano-iron supplement versus standard treatment for iron deficiency anaemia in children 6-35 months (IHAT-GUT trial)
Nuredin I Mohammed, James Wason, Thomas Mendy, Stefan A Nass, Ogochukwu Ofordile, Famalang Camara, Bakary Baldeh, Chilel Sanyang, Amadou T Jallow, Ilias Hossain, Nuno Faria, Jonathan J Powell, Andrew M Prentice, Dora Ia Pereira
Apr 07, 2023
BACKGROUND: Iron deficiency anaemia (IDA) is the leading cause of years lost to disability in most sub-Saharan African countries and is especially common in young children. The IHAT-GUT trial assessed the efficacy and safety of...
Biomarker-guided trials
M Antoniou, R Kolamunnage-Dona, J Wason, R Bathia, C Billingham, JM Bliss, LC Brown, A Gillman, J Paul, AL Jorgensen
Dec 09, 2019
Biomarker-guided trials have drawn considerable attention as they promise to lead to improvements in the benefit-risk ratio of treatments and enhanced opportunities for drug development. A variety of such designs have been...
Capturing the systemic immune signature of a norovirus infection
Antony J Cutler, Joao Oliveira, Ricardo C Ferreira, Ben Challis, Neil M Walker, Sarah Caddy, Jia Lu, Helen E Stevens, Deborah J Smyth, Marcin L Pekalski, Jane Kennet, Kara MD Hunter, Ian Goodfellow, Linda S Wicker, John A Todd, Frank Waldron-Lynch
Sep 05, 2018
BACKGROUND: The infection of a participant with norovirus during the adaptive study of interleukin-2 dose on regulatory T cells in type 1 diabetes (DILT1D) allowed a detailed insight into the cellular and cytokine immune...
Improving outcomes in adults with epilepsy and intellectual disability (EpAID) using a nurse-led intervention
Howard Ring, Nakita Gilbert, Roxanne Hook, Adam Platt, Christopher Smith, Fiona Irvine, Cam Donaldson, Elizabeth Jones, Joanna Kelly, Adrian Mander, Caroline Murphy, Mark Pennington, Angela Pullen, Marcus Redley, Simon Rowe, James Wason
Jun 09, 2016
clinical trial Clinical trials unit Cluster trial Controlled trial cost-effectiveness Epilepsy Epilepsy nurse Intellectual Disability Nurse-led intervention Pragmatic Quality of life Randomised Treatment Treatment as usual Adult Clinical Protocols Data Collection Epilepsy Humans Intellectual Disability Nurses Outcome Assessment Health Care qualitative research Research Design Sample Size
Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers.
Lucy Yang, Joseph Cheriyan, David D Gutterman, Ruth J Mayer, Zsuzsanna Ament, Jules L Griffin, Aili L Lazaar, David E Newby, Ruth Tal-Singer, Ian B Wilkinson
Jan 25, 2017
COPD EETs clinical trial endothelial function smokers soluble epoxide hydrolase inhibitor 8 11 14-Eicosatrienoic Acid Adult Aged blood vessels Bradykinin Case-Control Studies Cyclohexylamines Endothelium Vascular Epoxide Hydrolases Fluconazole Forearm Humans In Vitro Techniques Male Middle Aged Overweight Plethysmography Pulmonary Disease Chronic Obstructive Smoking Triazines Vasodilation Vasodilator Agents
Stem Cell Therapies for Progressive Multiple Sclerosis.
Jayden A Smith, Alexandra M Nicaise, Rosana-Bristena Ionescu, Regan Hamel, Luca Peruzzotti-Jametti, Stefano Pluchino
Jul 28, 2021
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with a relapsing-remitting (RR) disease course...
Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.
Aili L Lazaar, Lucy Yang, Rebecca L Boardley, Navin S Goyal, Jonathan Robertson, Sandra J Baldwin, David E Newby, Ian B Wilkinson, Ruth Tal-Singer, Ruth J Mayer, Joseph Cheriyan
May 04, 2016
COPD CLINICAL PHARMACOLOGY clinical trial Smoking soluble epoxide hydrolase 8 11 14-Eicosatrienoic Acid Adolescent Adult Aged Cohort Studies Cross-Over Studies Cyclohexylamines Dermatitis Contact Double-Blind Method Enzyme Inhibitors Epoxide Hydrolases Female Half-Life Headache Healthy Volunteers Humans Male Middle Aged obesity Triazines Young Adult
Prism Adaptation in Rehabilitation? No Additional Effects of Prism Adaptation on Neglect Recovery in the Subacute Phase Poststroke
Antonia F. Ten Brink, Johanna M a Visser-Meily, Martijn J. Schut, Mirjam Kouwenhoven, Anja L H Eijsackers, Tanja C.W. Nijboer
Dec 01, 2017
Background. Patients with neglect ignore or respond slower to contralesional stimuli. Neglect negatively influences independence in activities of daily living (ADL). Prism adaptation (PA) is one of the most frequently studied...
Overcoming hurdles to intervention studies with autistic children with profound communication difficulties and their families.
Ailbhe McKinney, Emma JL Weisblatt, Kathryn L Hotson, Zahra Bilal Ahmed, Claudia Dias, Dorit BenShalom, Juliet Foster, Suzanne Murphy, Sofía S Villar, Matthew K Belmonte
Jul 30, 2021
Autistic children who speak few or no words or who have an intellectual disability are the most in need of new understandings and treatments, but the most often left out of the research that can bring these benefits. Researchers...
MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
Robin B Brown, Daniel J Tozer, Laurence Loubière, Young T Hong, Tim D Fryer, Guy B Williams, Martin J Graves, Franklin I Aigbirhio, John T O'Brien, Hugh S Markus
Sep 03, 2022
Background: Cerebral small vessel disease (SVD) is a common cause of stroke and cognitive impairment. Recent data has implicated neuroinflammation and increased blood-brain barrier (BBB) permeability in its pathogenesis, but...
Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse.
Matthew David Morgan, Matthew Szeto, Michael Walsh, David Jayne, Kerstin Westman, Niels Rasmussen, Thomas F Hiemstra, Oliver Flossmann, Annelies Berden, Peter Höglund, Lorraine Harper, European Vasculitis Society
Jun 08, 2017
ANCA ANCA-associated vasculitis clinical trial prognostic factors Relapse Treatment Vasculitis Adult Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic cyclophosphamide Disease-Free Survival Female Humans Immunosuppressive Agents Maintenance Chemotherapy Male Middle Aged Outcome Assessment Health Care Proportional Hazards Models Randomized Controlled Trials as Topic Recurrence Remission Induction Retrospective Studies Risk Factors
Risk of contamination when planning psychological therapy trials can be assessed using a simple framework
Objectives: The objective of this study was to develop and pilot a standard framework that could be used to assess risk of contamination in psychological therapy trials, at the protocol development stage. Study Design and...
Managing uncertain recovery for patients nearing the end of life in hospital
J. Koffman, E. Yorganci, D. Yi, W. Gao, F. Murtagh, A. Pickles, S. Barclay, H. Johnson, R. Wilson, L. Sampson, J. Droney, M. Farquhar, T. Prevost, C. J. Evans
Aug 15, 2020
Abstract: Background: The AMBER (Assessment, Management, Best Practice, Engagement, Recovery Uncertain) care bundle is a complex intervention used in UK hospitals to support patients with uncertain recovery. However, it has yet...
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