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Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Anna M Nicholson, Cora Olpe, Alice Hoyle, Ann-Sofie Thorsen, Teja Rus, Mathilde Colombé, Roxanne Brunton-Sim, Richard Kemp, Kate Marks, Phil Quirke, Shalini Malhotra, Rogier Ten Hoopen, Ashraf Ibrahim, Cecilia Lindskog, Meagan B Myers, Barbara Parsons, Simon Tavaré, Mark Wilkinson, Edward Morrissey, Douglas J Winton
Aug 16, 2018
We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately...
clone Colon crypt dynamics Epithelium Expansion fission human Mutation Stem Cells Adolescent Adult Aged Aged 80 and over Algorithms Alleles Antigens Nuclear Cell Cycle Proteins Child Colon Epithelial Cells Epithelium Humans Middle Aged Models Statistical Monoamine Oxidase Mutation Stem Cells Young Adult