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Cortical atrophy and amyloid and tau deposition in Down syndrome
Concepcion Padilla, Victor Montal, Madeleine J Walpert, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Sigan L Hartley, Ann D Cohen, Dana L Tudorascu, Bradley T Christian, Benjamin L Handen, William E Klunk, Anthony J Holland, Shahid H Zaman
Apr 01, 2022
Abstract: Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at...