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Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.
Shuang Sun, Ismael Compañón, Nuria Martínez-Sáez, João D Seixas, Omar Boutureira, Francisco Corzana, Gonçalo JL Bernardes
Jun 08, 2018
We present a new peptide-macrocyclization strategy with an isobutylene graft. The reaction is mild and proceeds rapidly and efficiently both for linear and cyclic peptides. The resulting isobutylene-grafted peptides possess...
Intracellular application of an asparaginyl endopeptidase for producing recombinant head-to-tail cyclic proteins
Peptide backbone cyclization is commonly observed in nature and is increasingly applied to proteins and peptides to improve thermal and chemical stability and resistance to proteolytic enzymes and enhance biological activity....
OaAEP1 RiPPs asparaginyl endopeptidases cyclic peptides peptide ligation ribosomally synthesized and post-translationally modified peptides /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1601 name=Chemistry (miscellaneous) /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry
Intracellular application of an asparaginyl endopeptidase for producing recombinant head-to-tail cyclic proteins
Peptide backbone cyclization is commonly observed in nature and is increasingly applied to proteins and peptides to improve thermal and chemical stability and resistance to proteolytic enzymes and enhance biological activity....
OaAEP1 RiPPs asparaginyl endopeptidases cyclic peptides peptide ligation ribosomally synthesized and post-translationally modified peptides /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1601 name=Chemistry (miscellaneous) /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry