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Dendritic Cells Charged with Apoptotic Tumor Cells Induce Long-Lived Protective CD4+ and CD8+ T Cell Immunity against B16 Melanoma
Dendritic cells (DCs) are potent APCs and attractive vectors for cancer immunotherapy. Using the B16 melanoma, a poorly immunogenic experimental tumor that expresses low levels of MHC class I products, we investigated whether...
Apoptosis bone marrow cell antigen recognition cytokine release lymph node lymphatic drainage melanoma cell tumor immunity
Published by: Rockefeller University
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
During the innate response to many inflammatory and infectious stimuli, dendritic cells (DCs) undergo a differentiation process termed maturation. Mature DCs activate antigen-specific naive T cells. Here we show that both...
antigen expression dendritic cell cytokine release interleukin 2 Immunoregulation Signal Transduction
Published by: Rockefeller University