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[No abstract available]

Antigen Presentation Cell culture cytotoxic T lymphocyte dendritic cell natural killer cell

We have evaluated the capacity of dendritic ceUs to function as antigen-presenting cells (APCs) for influenza and have examined their mechanism of action. Virus-pulsed dendritic cells were 100 times more efficent than bulk...

antigen presenting cell cell function cytotoxic T lymphocyte dendritic cell Influenza virus protein synthesis spleen cell T lymphocyte ultraviolet irradiation Virus Replication

Inaba, K., Young, J.W., and Steinman, R.M. Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166: 182-194, 1987

cytotoxic T lymphocyte dendritic cell Phenotype t lymphocyte activation

The Epstein-Barr virus (EBV)-encoded nuclear antigen EBNA1 is critical for the persistence of the viral episome in replicating EBV-transformed human B cells. Therefore, all EBV-induced tumors express this foreign antigen....

Epstein Barr virus antigen B lymphocyte cytotoxic T lymphocyte dendritic cell episome

The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to...

cytotoxic T lymphocyte immune synapse secretion Animals Cell Membrane Cilia Humans Immunological Synapses Receptors Antigen T-Cell Signal Transduction T-Lymphocytes Cytotoxic

This study establishes that dendritic cells (DC) are the critical accessory cells for the development of anti-trinitrophenol (TNP) cytotoxic T lymphocytes (CTL) in vitro. We developed a model in which nylon wool-nonadherent...

cytotoxic T lymphocyte Dendritic Cells langerhans cell macrophage spleen cell

Preclinical data are reported that support a human immunodeficiency virus (HIV) vaccine strategy using recombinant canarypox-HIV vectors (ALVAC-HIV) to load human dendritic cells (DCs) with HIV antigens. Clinical-grade DCs were...

Canarypox virus cytotoxic T lymphocyte dendritic cell HIV Flow Cytometry Immunohistochemistry t lymphocyte activation

Airways infection with Mycobacterium tuberculosis (Mtb) is contained mostly by T cell responses, however, Mtb has developed evasion mechanisms which affect antigen presenting cell (APC) maturation/recruitment delaying the onset...

Antigen-Presenting Cells Bacterial Load Interferon-gamma Flow Cytometry cytotoxic T lymphocyte Peptide

Nussenzweig, M.C., Steinman, R.M., Gutchinov, B., and Cohn, Z.A. Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J. Exp. Med. 152: 1070-1084, 1980

cytotoxic T lymphocyte Dendritic Cells langerhans cell macrophage spleen cell

[No abstract available]

cytotoxic T lymphocyte dendritic cell Phenotype t lymphocyte activation

BACKGROUND: Familial hemophagocytic lymphohistiocytosis (FHL) is a rare and often fatal disorder characterized by defective cellular cytotoxicity and hyperinflammation, and the only cure known to date is hematopoietic stem cell...

Griscelli syndrome type 2 Hemophagocytic lymphohistiocytosis cytotoxic T lymphocyte familial hemophagocytic lymphohistiocytosis melanophilin natural killer cells Adaptor Proteins Signal Transducing Adolescent Albinism Case-Control Studies Cell Degranulation Cell Line Child Child Preschool Cohort Studies Cytotoxicity Immunologic DNA Mutational Analysis Female Gene Expression Genetic Markers Humans Infant Lymphohistiocytosis Hemophagocytic Male Membrane Proteins Models Molecular Mutation Perforin Phenotype Protein Binding Protein Conformation Skin Pigmentation rab GTP-Binding Proteins rab27 GTP-Binding Proteins

[No abstract available]

Cell transplantation dendritic cell cytotoxic T lymphocyte tumor immunity

Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously with a control injection of...

antigen presenting cell cytotoxic T lymphocyte dendritic cell human tissue immunomodulation

Young, J.W., and Steinman, R.M. Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. J. Exp. Med. 171: 1315-1332, 1990

Antigen Presentation Cell culture cytotoxic T lymphocyte dendritic cell natural killer cell

Natural killer T (NKT) cells are distinct glycolipid reactive innate lymphocytes that are implicated in the resistance to pathogens and tumors. Earlier attempts to mobilize NKT cells, specifically, in vivo in humans met with...

utoimmune disease cancer immunotherapy cytokine production Cytomegalovirus cytotoxic T lymphocyte dendritic cell natural killer cell Vaccination