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BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...

adaptive design Bayesian dose escalation phase I Bayes Theorem covid-19 Dose-Response Relationship Drug Humans Maximum Tolerated Dose Pandemics Research Design SARS-CoV-2

BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...

Research Bayesian phase I adaptive design dose escalation

INTRODUCTION: The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the...

adaptive designs Continual reassessment method dose escalation Dose-finding Maximum Tolerated Dose phase I trials Clinical Trials Phase I as Topic Computer Simulation Dose-Response Relationship Drug Humans Maximum Tolerated Dose Research Design

adaptive designs Bayesian methods Clinical Trials dose escalation Model-free Time-to-event

BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems...

Study Protocol opiate Addiction dependence GABA-B Baclofen Methadone phase I dose escalation Adaptive Bayesian

adaptive design dose escalation dual-agent trial nonparametric phase I clinical trial Antineoplastic Combined Chemotherapy Protocols Clinical Trials Phase I as Topic Computer Simulation Dose-Response Relationship Drug Humans Logistic Models Maximum Tolerated Dose Research Design statistics Nonparametric

BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems...

Adaptive Addiction Baclofen Bayesian dependence dose escalation GABA-B Methadone opiate phase I Humans Analgesics Opioid Baclofen Bayes Theorem Carbon Dioxide Cholecalciferol GABA-B Receptor Agonists Hypnotics and Sedatives Methadone Nicotine Opiate substitution treatment Opioid-Related Disorders Single-Blind Method vitamin D