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Stages, scaffolds and strings in the spatial organisation of non-homologous end joining
Shikang Liang, Amanda K Chaplin, Antonia Kefala Stavridi, Robert Appleby, Ales Hnizda, Tom L Blundell
Jan 20, 2021
Non-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the...
NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair.
Deeksha Munnur, Joanna Somers, George Skalka, Ria Weston, Rebekah Jukes-Jones, Mohammed Bhogadia, Cyril Dominguez, Kelvin Cain, Ivan Ahel, Michal Malewicz
Feb 11, 2019
Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to...
DNA Repair DNA-PK DSB NHEJ NR4A PARP double-strand breaks Non-homologous end joining poly-ADP-ribose Transcription Factors Binding Sites Cell Line Tumor DNA Repair DNA-Activated Protein Kinase HEK293 Cells Humans Nuclear Receptor Subfamily 4 Group A Member 1 Poly ADP Ribosylation Poly Adenosine Diphosphate Ribose Protein Binding Zinc Fingers