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ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron
Oct 26, 2020
The small molecule ISRIB antagonizes the activation of the integrated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(αP). ISRIB and eIF2(αP) bind distinct sites in their common target, eIF2B, a...
CRISPR/Cas9-homologous recombination cell stress drug action Eukaryotic Initiation Factor-2B mRNA translation Phosphorylation Protein Binding protein biosynthesis/drug effects Protein Conformation Acetamides Allosteric Regulation Animals Binding Sites CHO Cells Cricetulus Cryoelectron Microscopy Cyclohexylamines Eukaryotic Initiation Factor-2 Eukaryotic Initiation Factor-2B HeLa Cells Humans Phosphorylation