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mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
Joseph A Waldron, David C Tack, Laura E Ritchey, Sarah L Gillen, Ania Wilczynska, Ernest Turro, Philip C Bevilacqua, Sarah M Assmann, Martin Bushell, John Le Quesne
Feb 24, 2020
BACKGROUND: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in...
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
Joseph A Waldron, David C Tack, Laura E Ritchey, Sarah L Gillen, Ania Wilczynska, Ernest Turro, Philip C Bevilacqua, Sarah M Assmann, Martin Bushell, John Le Quesne
Feb 02, 2020
Translation Cancer RNA structure Translation initiation DMS G-Quadruplexes eIF4A Polysome profiling Hippuristanol Structure-seq
Published by: Genome biology, volume 20, issue 1
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity
Joseph A. Waldron, David C. Tack, Laura E. Ritchey, Sarah L. Gillen, Ania Wilczynska, Ernest Turro, Philip C. Bevilacqua, Sarah M. Assmann, Martin Bushell, John Le Quesne
Dec 29, 2020
Abstract: Background: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1...