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Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1
JT Chenge, LV Duyet, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys, AW Munro
Mar 10, 2017
A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I.
Mikhail A Hameedi, Daniel N Grba, Katherine H Richardson, Andrew JY Jones, Wei Song, Maxie M Roessler, John J Wright, Judy Hirst
May 17, 2021
Respiratory complex I (NADH:ubiquinone oxidoreductase), the first enzyme of the electron-transport chain, captures the free energy released by NADH oxidation and ubiquinone reduction to translocate protons across an...
Probing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR Spectroscopy.
Claire Bagnéris, Kacper B Rogala, Mehdi Baratchian, Vlad Zamfir, Micha BA Kunze, Selina Dagless, Katharina F Pirker, Mary K Collins, Benjamin A Hall, Tracey E Barrett, Christopher WM Kay
Sep 05, 2018
Viral flice-interacting protein (vFLIP), encoded by the oncogenic Kaposi sarcoma-associated herpes virus (KSHV), constitutively activates the canonical nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) pathway....
IKKγ NEMO NF-kappa B (NF-κB) electron paramagnetic resonance (EPR) Molecular dynamics molecular modeling Protein Structure signalosome vFLIP Virology Amino Acid Motifs Binding Sites Electron Spin Resonance Spectroscopy Herpesvirus 8 Human Humans I-kappa B Kinase Protein Binding Sarcoma Kaposi Viral Proteins