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Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes
A Multicenter Cost-of-Illness and Long-term Socioeconomic Follow-up Study in the Severe Typhoid Fever in Africa Program
Enusa Ramani, Seeun Park, Trevor Toy, Ursula Panzner, Ondari D Mogeni, Justin Im, Ligia Maria Cruz Espinoza, Hyon Jin Jeon, Gi Deok Pak, Hyeongwon Seo, Yun Chon, Raphaël Rakotozandrindrainy, Ellis Owusu-Dabo, Isaac Osei, Abdramane Bassiahi Soura, Mekonnen Teferi, Florian Marks, Vittal Mogasale
Nov 26, 2019
BACKGROUND: There are limited data on typhoid fever cost of illness (COI) and economic impact from Africa. Health economic data are essential for measuring the cost-effectiveness of vaccination or other disease control...
Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal.
Thomas C Darton, Claire Jones, Sabina Dongol, Merryn Voysey, Christoph J Blohmke, Rajendra Shrestha, Abhilasha Karkey, Mila Shakya, Amit Arjyal, Claire S Waddington, Malick Gibani, Michael J Carter, Buddha Basnyat, Stephen Baker, Andrew J Pollard
Apr 10, 2019
New diagnostic tests for enteric fever are urgently needed to assist with timely antimicrobial treatment of patients and to measure the efficacy of prevention measures such as vaccination. In a novel translational approach, here...
Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model.
Hazel C Dobinson, Malick M Gibani, Claire Jones, Helena B Thomaides-Brears, Merryn Voysey, Thomas C Darton, Claire S Waddington, Danielle Campbell, Iain Milligan, Liqing Zhou, Sonu Shrestha, Simon A Kerridge, Anna Peters, Zoe Stevens, Audino Podda, Laura B Martin, Flavia D'Alessio, Duy Pham Thanh, Buddha Basnyat, Stephen Baker, Brian Angus, Myron M Levine, Christoph J Blohmke, Andrew J Pollard
Apr 10, 2019
BACKGROUND: To expedite the evaluation of vaccines against paratyphoid fever, we aimed to develop the first human challenge model of Salmonella enterica serovar Paratyphi A infection. METHODS: Two groups of 20 participants...
Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes.
Carl D Britto, Sitarah Mathias, Ashish Bosco, Zoe A Dyson, Gordon Dougan, Savitha Raveendran, VL Abin, Sanju Jose, Savitha Nagaraj, Kathryn E Holt, Andrew J Pollard
Sep 21, 2020
BACKGROUND: India is endemic for enteric fever, and it is not known whether the variations in clinical manifestations between patients are due to host, environmental or pathogen factors.Blood culture surveillance was conducted...
Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia
Abhishek Giri, Abhilasha Karkey, Sabina Dongol, Amit Arjyal, Archana Maharjan, Balaji Veeraraghavan, Buddhi Paudyal, Christiane Dolecek, Damodar Gajurel, Dung Nguyen Thi Phuong, Duy Pham Thanh, Farah Qamar, Gagandeep Kang, Ho Van Hien, Jacob John, Katrina Lawson, Marcel Wolbers, Md Shabab Hossain, M Sharifuzzaman, Nantasit Luangasanatip, Nhukesh Maharjan, Piero Olliaro, Priscilla Rupali, Ronas Shakya, Sadia Shakoor, Samita Rijal, Sonia Qureshi, Stephen Baker, Subi Joshi, Tahmeed Ahmed, Thomas Darton, Tran Nguyen Bao, Yoel Lubell, Evelyne Kestelyn, Guy Thwaites, Christopher M Parry, Buddha Basnyat
Mar 05, 2022
Background: Typhoid and paratyphoid fever (enteric fever) is a common cause of non-specific febrile infection in adults and children presenting to health care facilities in low resource settings such as the South Asia. A 7-day...
Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases.
Christoph J Blohmke, Julius Muller, Malick M Gibani, Hazel Dobinson, Sonu Shrestha, Soumya Perinparajah, Celina Jin, Harri Hughes, Luke Blackwell, Sabina Dongol, Abhilasha Karkey, Fernanda Schreiber, Derek Pickard, Buddha Basnyat, Gordon Dougan, Stephen Baker, Andrew J Pollard, Thomas C Darton
Oct 31, 2019
Misdiagnosis of enteric fever is a major global health problem, resulting in patient mismanagement, antimicrobial misuse and inaccurate disease burden estimates. Applying a machine learning algorithm to host gene expression...
An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.
Nga Tran Vu Thieu, Tan Trinh Van, Anh Tran Tuan, Elizabeth J Klemm, Chau Nguyen Ngoc Minh, Phat Voong Vinh, Duy Pham Thanh, Thanh Ho Ngoc Dan, Trung Pham Duc, Pinky Langat, Laura B Martin, Jorge Galan, Li Liang, Philip L Felgner, D Huw Davies, Hanna K de Jong, Rapeephan R Maude, Masako Fukushima, Lalith Wijedoru, Aniruddha Ghose, Rasheda Samad, Arjen M Dondorp, Abul Faiz, Thomas C Darton, Andrew J Pollard, Guy E Thwaites, Gordon Dougan, Christopher M Parry, Stephen Baker
Apr 10, 2019
OBJECTIVES: The diagnosis of typhoid fever is a challenge. Aiming to develop a typhoid diagnostic we measured antibody responses against Salmonella Typhi (S. Typhi) protein antigens and the Vi polysaccharide in a cohort of...
Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes
Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array.
Thomas C Darton, Stephen Baker, Arlo Randall, Sabina Dongol, Abhilasha Karkey, Merryn Voysey, Michael J Carter, Claire Jones, Krista Trappl, Jozelyn Pablo, Chris Hung, Andy Teng, Adam Shandling, Tim Le, Cassidy Walker, Douglas Molina, Jason Andrews, Amit Arjyal, Buddha Basnyat, Andrew J Pollard, Christoph J Blohmke
Apr 10, 2019
Current diagnostic tests for typhoid fever, the disease caused by Salmonella Typhi, are poor. We aimed to identify serodiagnostic signatures of typhoid fever by assessing microarray signals to 4,445 S. Typhi antigens in sera...
The STRATAA study protocol
Thomas C Darton, James E Meiring, Susan Tonks, Md Arifuzzaman Khan, Farhana Khanam, Mila Shakya, Deus Thindwa, Stephen Baker, Buddha Basnyat, John D Clemens, Gordon Dougan, Christiane Dolecek, Sarah J Dunstan, Melita A Gordon, Robert S Heyderman, Kathryn E Holt, Virginia E Pitzer, Firdausi Qadri, K Zaman, Andrew J Pollard, STRATAA Study Consortium
Apr 10, 2019
INTRODUCTION: Invasive infections caused by Salmonella enterica serovar Typhi and Paratyphi A are estimated to account for 12-27 million febrile illness episodes worldwide annually. Determining the true burden of typhoidal...
Africa Asia Diagnosis enteric fever febrile illness healthcare utilisation infection transmission resource-limited setting Salmonella paratyphi A Salmonella typhi seroepidemiology serosurveillance vaccination programme Adolescent Bangladesh Carrier State Censuses Child Child Preschool Cost of Illness Female Health Resources Humans Incidence Infant Infant Newborn Malawi Male Models Theoretical Nepal Patient Acceptance of Health Care Population Surveillance Research Design Seroepidemiologic Studies Surveys and Questionnaires Typhoid Fever
Co-trimoxazole versus azithromycin for the treatment of undifferentiated febrile illness in Nepal
Sunil Pokharel, Buddha Basnyat, Amit Arjyal, Saruna Pathak Mahat, Raj Kumar Kc, Abhusani Bhuju, Buddhi Poudyal, Evelyne Kestelyn, Ritu Shrestha, Dung Nguyen Thi Phuong, Rajkumar Thapa, Manan Karki, Sabina Dongol, Abhilasha Karkey, Marcel Wolbers, Stephen Baker, Guy Thwaites
Apr 10, 2019
BACKGROUND: Undifferentiated febrile illness (UFI) includes typhoid and typhus fevers and generally designates fever without any localizing signs. UFI is a great therapeutic challenge in countries like Nepal because of the lack...
Azithromycin Co-trimoxazole enteric fever Fever clearance time Undifferentiated febrile illness Administration Oral Adolescent Adult Aged Anti-Bacterial Agents Azithromycin Child Child Preschool Clinical Protocols Double-Blind Method Drug Resistance Bacterial Female Fever Humans Male Middle Aged Nepal Research Design Time Factors Treatment Outcome Trimethoprim Sulfamethoxazole Drug Combination Typhoid Fever Typhus Epidemic Louse-Borne Young Adult
Very long O-antigen chains of Salmonella Paratyphi A inhibit inflammasome activation and pyroptotic cell death.
Elli Mylona, Julia Sanchez-Garrido, Trang Nguyen Hoang Thu, Sabina Dongol, Abhilasha Karkey, Stephen Baker, Avinash R Shenoy, Gad Frankel
Jan 22, 2021
Salmonella Paratyphi A (SPtA) remains one of the leading causes of enteric (typhoid) fever. Yet, despite the recent increased rate of isolation from patients in Asia, our understanding of its pathogenesis is incomplete. Here we...
FepE O-antigen Salmonella paratyphi A Salmonella typhimurium caspase-4 enteric fever Inflammasomes pyroptosis Bacterial Proteins Caspases HeLa Cells Humans Inflammasomes Intracellular Signaling Peptides and Proteins MACROPHAGES O Antigens Paratyphoid Fever Phosphate-Binding Proteins pyroptosis Salmonella paratyphi A THP-1 Cells Type III Secretion Systems Virulence Virulence Factors
Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance
Corinne N Thompson, Abhilasha Karkey, Sabina Dongol, Amit Arjyal, Marcel Wolbers, Thomas Darton, Jeremy J Farrar, Guy E Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker
Apr 10, 2019
BACKGROUND.: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia. METHODS.: Individual data from 2092 patients with enteric fever randomized into...
Nepal Antimicrobial resistance enteric fever fluoroquinolone typhoid Adolescent Adult Anti-Bacterial Agents Azithromycin Ceftriaxone Child Drug Resistance Multiple Bacterial Female Fluoroquinolones Gatifloxacin Humans Male Microbial Sensitivity Tests Nepal Ofloxacin Paratyphoid Fever Salmonella paratyphi A Salmonella typhi Treatment Failure Treatment Outcome Typhoid Fever Young Adult
Salmonella Paratyphi A Outer Membrane Vesicles Displaying Vi Polysaccharide as a Multivalent Vaccine against Enteric Fever.
G Gasperini, R Alfini, V Arato, F Mancini, MG Aruta, P Kanvatirth, D Pickard, F Necchi, A Saul, O Rossi, F Micoli, P Mastroeni
Dec 11, 2020