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Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination.
Louise S Matheson, Daniel J Bolland, Peter Chovanec, Felix Krueger, Simon Andrews, Hashem Koohy, Anne E Corcoran
Jun 24, 2019
V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows immunoglobulin heavy chain (Igh) recombination. We...
Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.
Liane Dupont, Lily Du, Madeleine Poulter, Stephanie Choi, Megan McIntosh, Matthew B Reeves
Feb 25, 2021
Human cytomegalovirus (HCMV) latency and reactivation rely on a complex interplay between cellular differentiation, cell signaling pathways, and viral gene functions. HCMV reactivation in dendritic cells (DCs) is triggered by...
Cell Signaling chromatin modification cytomegalovirus reactivation epigenetic regulation Gene Expression hematopoietic cell kinase herpesvirus histone acetylation lysine acetyltransferase 6A (KAT6A) Phosphoproteomics Cells Cultured Cytomegalovirus Histone Acetyltransferases Humans Promoter Regions Genetic Virus Activation Zinc Fingers src-Family Kinases
Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.
Yun Hsiao Lin, Yue Liang, Hanchen Wang, Lin Tze Tung, Michael Förster, Poorani Ganesh Subramani, Javier M Di Noia, Simon Clare, David Langlais, Anastasia Nijnik
Jun 07, 2021
BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other substrates. BAP1 is an important...
B Cell Development B cells epigenetic regulation Mouse models Transcriptional regulation Animals B-Lymphocytes Cell Lineage Cell Proliferation Cells Cultured Epigenesis Genetic Female Gene Expression Regulation Developmental Histones Lymphocyte Activation Male Mice Inbred C57BL Mice Knockout Phenotype Precursor Cells B-Lymphoid Protein Processing Post-Translational Transcription Genetic Tumor Suppressor Proteins Ubiquitin Thiolesterase Ubiquitination
Strain-Specific Epigenetic Regulation of Endogenous Retroviruses
Approximately 10 percent of the mouse genome consists of endogenous retroviruses (ERVs), relics of ancient retroviral infections that are classified based on their relatedness to exogenous retroviral genera. Because of the...
Developmental Restriction of Retrotransposition Activated in Arabidopsis by Environmental Stress.
Retrotransposons (RTs) can rapidly increase in copy number due to periodic bursts of transposition. Such bursts are mutagenic and thus potentially deleterious. However, certain transposition-induced gain-of-function or...
Strain-Specific Epigenetic Regulation of Endogenous Retroviruses
Approximately 10 percent of the mouse genome consists of endogenous retroviruses (ERVs), relics of ancient retroviral infections that are classified based on their relatedness to exogenous retroviral genera. Because of the...
ERVs KRAB zinc finger proteins epigenetic regulation metastable epialleles modifiers strain-specific Transgenes Animals endogenous retroviruses Epigenesis Genetic Gene Expression Regulation Humans Kruppel-Like Transcription Factors Mice Mice Inbred Strains Promoter Regions Genetic Retroviridae Infections Trans-Activators
Recent Advances in Imprinting Disorders.
L Soellner, M Begemann, DJG Mackay, K Grønskov, Z Tümer, ER Maher, IK Temple, D Monk, A Riccio, A Linglart, I Netchine, T Eggermann
Aug 05, 2016