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We present EPISPOT, a fully joint framework which exploits large panels of epigenetic annotations as variant-level information to enhance molecular quantitative trait locus (QTL) mapping. Thanks to a purpose-built Bayesian...

epigenetic annotations hierarchical modelling large-scale multivariate mapping molecular QTL studies trans hotspots variational EM algorithm Algorithms Bayes Theorem Chromosome Mapping Computer Simulation epigenome Humans Models Genetic Mutation Phenotype Quantitative Trait Loci