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Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Jessica M Froula, Marta Castellana-Cruz, Nadia M Anabtawi, José D Camino, Serene W Chen, Drake R Thrasher, Jennifer Freire, Allen A Yazdi, Sheila Fleming, Christopher M Dobson, Janet R Kumita, Nunilo Cremades, Laura A Volpicelli-Daley
May 31, 2019
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusions composed of aggregated α-synuclein (α-syn). These inclusions are associated with behavioral and pathological PD phenotypes....
LEWY BODY Parkinson's Disease Amyloid Cytotoxicity fibril motor-behavior defect Neurodegenerative disease oligomer protein aggregation α-synuclein Amyloid Animals Behavior Animal Corpus Striatum Disease Models Animal Dopaminergic Neurons Male Mice Parkinson Disease Phenotype Protein Aggregates Protein Conformation beta-Strand ALPHA-SYNUCLEIN
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.
Franziska Kundel, Laura Tosatto, Daniel R Whiten, David C Wirthensohn, Mathew H Horrocks, David Klenerman
May 16, 2018
The link between protein aggregation and neurodegenerative disease is well established. However, given the heterogeneity of species formed during the aggregation process, it is difficult to delineate details of the molecular...