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Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation.
Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel IA Cohen, Georg Meisl, Johnny Habchi, Tuomas PJ Knowles, Michele Vendruscolo, Sara Linse
Jan 07, 2022
The self-assembly of the protein tau into neurofibrillary tangles is one of the hallmarks of Alzheimer's disease and related tauopathies. Still, the molecular mechanism of tau aggregation is largely unknown. This problem may be...