Search
Results: 2
In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors.
Jingxu Guo, Alice Douangamath, Weixiao Song, Alun R Coker, AW Edith Chan, Steve P Wood, Jonathan B Cooper, Efrat Resnick, Nir London, Frank von Delft
Sep 25, 2020
Outbreaks of human epidemic nonbacterial gastroenteritis are mainly caused by noroviruses. Viral replication requires a 3C-like cysteine protease (3CLpro) which processes the 200 kDa viral polyprotein into six functional...
Fragment screening against the EthR-DNA interaction by native mass spectrometry
DSH Chan, V Mendes, S Thomas, B McConnell, D Matak-Vinkovic, A Coyne, T Blundell, C Abell
Aug 18, 2017
Native nanoelectrospray ionization mass spectrometry is an underutilized technique for fragment screening. In this study, the first demonstration is provided of the use of native mass spectrometry for screening fragments against...