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Is Protein Folding a Thermodynamically Unfavorable, Active, Energy-Dependent Process?
The prevailing current view of protein folding is the thermodynamic hypothesis, under which the native folded conformation of a protein corresponds to the global minimum of Gibbs free energy G. We question this concept and show...
Pain
Ben Seymour
Feb 11, 2019
Since noxious stimulation usually leads to the perception of pain, pain has traditionally been considered sensory nociception. But its variability and sensitivity to a broad array of cognitive and motivational factors have meant...
active inference Active sensing Avoidance Learning computome endogenous modulation free energy information theory Optimal control pain and nociception pregenual anterior cingulate cortex Avoidance Learning Brain Cognition Conditioning Classical Conditioning Operant Humans learning motivation nociception Pain Pain Perception Reinforcement psychology
Is Protein Folding a Thermodynamically Unfavorable, Active, Energy-Dependent Process?
The prevailing current view of protein folding is the thermodynamic hypothesis, under which the native folded conformation of a protein corresponds to the global minimum of Gibbs free energy G. We question this concept and show...
co-translational protein folding energy-dependent protein folding Entropy free energy free energy landscape Molecular Chaperones physical model of protein folding Protein Folding Algorithms Kinetics Models Molecular Models Theoretical Protein Conformation Protein Folding Protein Refolding Protein Stability Proteins Proteome Proteomics Recombinant Proteins Solubility Species Specificity Thermodynamics
On Markov blankets and hierarchical self-organisation
Biological self-organisation can be regarded as a process of spontaneous pattern formation; namely, the emergence of structures that distinguish themselves from their environment. This process can occur at nested spatial...
active inference Dynamical systems free energy Markov blanket self-organisation /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/subjectarea/asjc/2400/2400 name=General Immunology and Microbiology /dk/atira/pure/subjectarea/asjc/1100/1100 name=General Agricultural and Biological Sciences /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
On Markov blankets and hierarchical self-organisation
Biological self-organisation can be regarded as a process of spontaneous pattern formation; namely, the emergence of structures that distinguish themselves from their environment. This process can occur at nested spatial...
active inference Dynamical systems free energy Markov blanket self-organisation /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/subjectarea/asjc/2400/2400 name=General Immunology and Microbiology /dk/atira/pure/subjectarea/asjc/1100/1100 name=General Agricultural and Biological Sciences /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics