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Inherited optic neuropathies, including Leber Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), are monogenetic diseases with a final common pathway of mitochondrial dysfunction leading to retinal ganglion...

DOA LHON OPA1 RNA-seq gene-therapy Mitochondrial Neuroprotection optic neuropathies transcriptomics Alleles Animals Disease Management Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease Genetic Therapy Genotype Humans Mutation Optic Atrophies Hereditary Phenotype Transcriptome

Inherited optic neuropathies, including Leber Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), are monogenetic diseases with a final common pathway of mitochondrial dysfunction leading to retinal ganglion...

transcriptomics RNA-seq Neuroprotection DOA OPA1 LHON gene-therapy Mitochondrial optic neuropathies