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Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase
Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood. The S-phase checkpoint for...
Checkpoint inhibition of origin firing prevents DNA topological stress.
Esther C Morafraile, Christine Hänni, George Allen, Theresa Zeisner, Caroline Clarke, Mark C Johnson, Miguel M Santos, Lauren Carroll, Nicola E Minchell, Jonathan Baxter, Peter Banks, Dave Lydall, Philip Zegerman
Sep 19, 2019
A universal feature of DNA damage and replication stress in eukaryotes is the activation of a checkpoint-kinase response. In S-phase, the checkpoint inhibits replication initiation, yet the function of this global block to...