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Results: 8
Return of individual research results from genomic research
Danya F Vears, Joel T Minion, Stephanie J Roberts, James Cummings, Mavis Machirori, Mwenza Blell, Isabelle Budin-Ljøsne, Lorraine Cowley, Stephanie OM Dyke, Clara Gaff, Robert Green, Alison Hall, Amber L Johns, Bartha M Knoppers, Stephanie Mulrine, Christine Patch, Eva Winkler, Madeleine J Murtagh
Jan 07, 2022
Public trust and genomic medicine in Canada and the UK.
Background: Genomic medicine could improve precise risk stratification, early prevention, and personalised treatment across a broad spectrum of disease. As this reality approaches, questions on the importance of public trust...
Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine
Bram Peter Prins, Liis Leitsalu, Katri Pärna, Krista Fischer, Andres Metspalu, Toomas Haller, Harold Snieder
Jun 04, 2021
The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial...
Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine
Bram Peter Prins, Liis Leitsalu, Katri Pärna, Krista Fischer, Andres Metspalu, Toomas Haller, Harold Snieder
Apr 30, 2021
The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial...
Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians.
Minxian Wang, Ramesh Menon, Sanghamitra Mishra, Aniruddh P Patel, Mark Chaffin, Deepak Tanneeru, Manjari Deshmukh, Oshin Mathew, Sanika Apte, Christina S Devanboo, Sumathi Sundaram, Praveena Lakshmipathy, Sakthivel Murugan, Krishna Kumar Sharma, Karthikeyan Rajendran, Sam Santhosh, Rajesh Thachathodiyl, Hisham Ahamed, Aniketh Vijay Balegadde, Thomas Alexander, Krishnan Swaminathan, Rajeev Gupta, Ajit S Mullasari, Alben Sigamani, Muralidhar Kanchi, Andrew S Peterson, Adam S Butterworth, John Danesh, Emanuele Di Angelantonio, Aliya Naheed, Michael Inouye, Rajiv Chowdhury, Ramprasad L Vedam, Sekar Kathiresan, Ravi Gupta, Amit V Khera
Jul 27, 2020
Delivering genomic medicine in the United Kingdom National Health Service
Caroline Pearce, Emma Goettke, Nina Hallowell, Pauline McCormack, Frances Flinter, Christopher McKevitt
Oct 01, 2020
PURPOSE: We sought to assess the readiness of the United Kingdom (UK) National Health Service to implement a Genomic Medicine Service. We conducted a systematic literature review to identify what is known about factors related...
DECIPHER
Julia Foreman, Simon Brent, Daniel Perrett, Andrew P Bevan, Sarah E Hunt, Fiona Cunningham, Matthew E Hurles, Helen V Firth
Feb 22, 2022
Evaluating variants classified as pathogenic in ClinVar in the DDD Study.
Caroline F Wright, Ruth Y Eberhardt, Panayiotis Constantinou, Matthew E Hurles, David R FitzPatrick, Helen V Firth, DDD Study
Mar 05, 2021
PURPOSE: Automated variant filtering is an essential part of diagnostic genome-wide sequencing but may generate false negative results. We sought to investigate whether some previously identified pathogenic variants may be being...