Search
Results: 17
Selective stimulation of colonic L cells improves metabolic outcomes in mice
Jo E. Lewis, Emily L. Miedzybrodzka, Rachel E. Foreman, Orla R. M. Woodward, Richard G. Kay, Deborah A. Goldspink, Fiona M. Gribble, Frank Reimann
Jun 10, 2020
Pregnane glycosides from Cynanchum menarandrense.
Michail Tsoukalas, Arianna Psichas, Frank Reimann, Fiona M Gribble, Annelise Lobstein, Aurélie Urbain
Sep 07, 2017
Glucagon-like peptide-1 secretion in people with <i>versus </i>without type 2 diabetes
Jon D. Watkins, Steven Carter, Greg Atkinson, Francoise Koumanov, James A. Betts, Jens Holst, Javier T. Gonzalez
Mar 31, 2023
Aims/Hypothesis: The aim of this systematic review was to synthesise the study findings on whether GLP-1 secretion in response to a meal tolerance test is affected by the presence of type 2 diabetes (T2D). The influence of...
Endocrinology glucagon-like peptide-1 Meta-Analysis Type 2 diabetes /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).
Cathryn Weston, Jing Lu, Naichang Li, Kerry Barkan, Gareth O Richards, David J Roberts, Timothy M Skerry, David Poyner, Meenakshi Pardamwar, Christopher A Reynolds, Simon J Dowell, Gary B Willars, Graham Ladds
Jul 24, 2015
Venous blood provides lower glucagon-like peptide-1 concentrations than arterialized blood in the postprandial but not the fasted state
Yung-Chih Chen, Robert Edinburgh, Aaron Hengist, Harry Smith, Jean-Philippe Walhin, James Betts, Dylan Thompson, Javier Gonzalez
Sep 01, 2018
New Findings: What is the central question of this study? Glucagon-like peptide-1 (GLP-1) is an important obesity/diabetes target, with effects dependent on circulating GLP-1 concentrations. Peripheral tissues extract GLP-1;...
Calcium ingestion suppresses appetite and produces acute overcompensation of energy intake independent of protein in healthy adults
Javier Gonzalez, Benjamin Paul Green, Meghan A Brown, Penny Louise Sheena Rumbold, Louise A Turner, Emma J Stevenson
Mar 01, 2015
Background: Prior evidence suggests that high-calcium intake influences postprandial appetite and insulinemia, possibly due to elevated incretins. In vitro and ex vivo models demonstrate that extracellular calcium and protein...
Selective stimulation of colonic L cells improves metabolic outcomes in mice.
Jo E Lewis, Emily L Miedzybrodzka, Rachel E Foreman, Orla RM Woodward, Richard G Kay, Deborah A Goldspink, Fiona M Gribble, Frank Reimann
Mar 04, 2020
Calcium ingestion suppresses appetite and produces acute overcompensation of energy intake independent of protein in healthy adults
Javier Gonzalez, Benjamin Paul Green, Meghan A Brown, Penny Louise Sheena Rumbold, Louise A Turner, Emma J Stevenson
Mar 01, 2015
Background: Prior evidence suggests that high-calcium intake influences postprandial appetite and insulinemia, possibly due to elevated incretins. In vitro and ex vivo models demonstrate that extracellular calcium and protein...
Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway
Joel P Giblett, Richard G Axell, Paul A White, Sophie J Clarke, Liam McCormick, Philip A Read, Johannes Reinhold, Adam J Brown, Michael O'Sullivan, Nick EJ West, David P Dutka, Stephen P Hoole
Sep 29, 2016
BACKGROUND: Glucagon-like peptide-1 (7-36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels...
Cardioprotection glucagon-like peptide-1 Ischemia–reperfusion injury KATP Adolescent Adult Aged Aged 80 and over Coronary Artery Disease Coronary Vessels Echocardiography Stress Female Glucagon-Like Peptide 1 Glyburide Humans Male Middle Aged Myocardial Ischemia Potassium Channels Ventricular Dysfunction Left Young Adult
Selective stimulation of colonic L cells improves metabolic outcomes in mice
Jo E. Lewis, Emily L. Miedzybrodzka, Rachel E. Foreman, Orla R. M. Woodward, Richard G. Kay, Deborah A. Goldspink, Fiona M. Gribble, Frank Reimann
Apr 27, 2021
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells
Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M. Shchepinova, Ivan R. Corrêa Jr, David J. Hodson, Johannes Broichhagen, Edward W. Tate, Frank Reimann, Victoria Salem, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Nov 10, 2020
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic...
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells.
Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M Shchepinova, Ivan R Corrêa, David J Hodson, Johannes Broichhagen, Edward W Tate, Frank Reimann, Victoria Salem, Guy A Rutter, Tricia Tan, Stephen R Bloom, Alejandra Tomas, Ben Jones
Jan 25, 2021
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic...
Venous blood provides lower glucagon-like peptide-1 concentrations than arterialized blood in the postprandial but not the fasted state
Yung-Chih Chen, Robert Edinburgh, Aaron Hengist, Harry Smith, Jean-Philippe Walhin, James Betts, Dylan Thompson, Javier Gonzalez
Sep 01, 2018
New Findings: What is the central question of this study? Glucagon-like peptide-1 (GLP-1) is an important obesity/diabetes target, with effects dependent on circulating GLP-1 concentrations. Peripheral tissues extract GLP-1;...
Glucagon-like peptide-1 secretion in people with <i>versus </i>without type 2 diabetes
Jon D. Watkins, Steven Carter, Greg Atkinson, Francoise Koumanov, James A. Betts, Jens Holst, Javier T. Gonzalez
Mar 31, 2023
Aims/Hypothesis: The aim of this systematic review was to synthesise the study findings on whether GLP-1 secretion in response to a meal tolerance test is affected by the presence of type 2 diabetes (T2D). The influence of...
Endocrinology glucagon-like peptide-1 Meta-Analysis Type 2 diabetes /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N. Christie, Shefeeq M. Theparambil, Sean M. Davidson, Frank Reimann, Stefan Trapp, Derek M. Yellon, Alexander V. Gourine
May 04, 2021
Abstract: Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct...