Search

CONTEXT: Meal timing affects metabolic homeostasis and body weight, but how composition and timing of meals affect plasma lipidomics in humans is not well studied. OBJECTIVE: We used high throughput shotgun plasma lipidomics to...

circadian clock glucose metabolism insulin sensitivity Lipid Metabolism meal timing plasma lipidome Adult Blood Glucose Carbohydrate Metabolism Circadian Rhythm Cross-Over Studies Diet High-Fat Dietary Carbohydrates Dietary Fats Germany Humans Insulin Insulin Resistance Lipid Metabolism lipidomics Male Meals Middle Aged Postprandial Period

Glucokinase (GK) is highly expressed in the hypothalamic paraventricular nucleus (PVN); however, its role is currently unknown. We found that GK in the PVN acts as part of a glucose-sensing mechanism within the PVN that...

Diabetes Endocrinology glucose metabolism neuroscience Peptides Animals Glucagon-Like Peptide 1 glucokinase Glucose Male Paraventricular Hypothalamic Nucleus Rats Rats Inbred WF

Metabolic derangements following traumatic brain injury are poorly characterized. In this single-centre observational cohort study we combined 18F-FDG and multi-tracer oxygen-15 PET to comprehensively characterize the extent and...

PET cerebral blood flow glucose metabolism Microdialysis Traumatic brain injury Adult Brain Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Female Glucose Humans Male Middle Aged Positron-Emission Tomography

Increased amyloid burden and decreased glucose metabolism are important characteristics of Alzheimer's disease (AD), but their spatial distribution and hierarchical clustering organization are still poorly understood. In this...

Alzheimer’s disease glucose metabolism hierarchical organization spatial distribution β-amyloid

Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very...

Alzheimer's Disease Breaks in sedentary time cognitive function Dementia Diabetes Exercise glucose metabolism Light-intensity activity physical activity Sedentary Behavior Sitting

Abstract: Aims/hypothesis: Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus...

article ER stress glucose metabolism Lunapark Maternal obesity miR-126-3p Nutritional programming

fetal growth Gestational diabetes glucose metabolism Insulin Resistance nutrient partitioning Pregnancy

CAPZ Capping protein F-actin dynamics Gluconeogenesis glucose metabolism Hepatocyte cell fate maintenance Hippo Liver homeostasis Mechanotransduction Organ growth Xenobiotic metabolism YAP

With an increasing prevalence of diabetes worldwide, effective dietary strategies for blood glucose control are crucial. As carbohydrates make up approximately 50% of the diet, it is neither practical nor advisable to avoid them...

food processing glucose metabolism glycaemic response stable isotopes Starch

Although exercise training is an important recommendation for the management of type 1 diabetes (T1D), most of the available research studies predominantly focus on male subjects. Given the importance of sex as a biological...

glucose metabolism streptozotocin Insulin chronic exercise hyperlipidemia Ketosis Endocrinology, Diabetes, and Metabolism Exercise Physiology

ER stress glucose metabolism Lunapark Maternal obesity Nutritional programming miR-126-3p 3T3-L1 Cells Adipocytes Adipose Tissue Animals Blood Glucose Disease Models Animal Down-Regulation Endoplasmic reticulum stress Female Homeodomain Proteins Insulin Receptor Substrate Proteins Insulin Resistance Mice Mice Inbred C57BL MicroRNAs obesity Maternal Phenotype Pregnancy prenatal exposure delayed effects Signal Transduction