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Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.
Katelyn Paz, Ryan Flynn, Jing Du, Stacey Tannheimer, Amy J Johnson, Shuai Dong, Anne-Katrien Stark, Klaus Okkenhaug, Angela Panoskaltsis-Mortari, Peter T Sage, Arlene H Sharpe, Leo Luznik, Jerome Ritz, Robert J Soiffer, Corey S Cutler, John Koreth, Joseph H Antin, David B Miklos, Kelli P MacDonald, Geoffrey R Hill, Ivan Maillard, Jonathan S Serody, William J Murphy, David H Munn, Colby Feser, Michael Zaiken, Bart Vanhaesebroeck, Laurence A Turka, John C Byrd, Bruce R Blazar
Feb 23, 2019
Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality following allotransplant. Activated donor effector T cells can differentiate into pathogenic T helper (Th)-17 cells and germinal center...
basic (laboratory) research/science graft-versus-host disease (GVHD) immunobiology immunosuppressant - other Animals B-Lymphocytes Bone Marrow Transplantation Bronchiolitis Obliterans Chronic Disease Class I Phosphatidylinositol 3-Kinases Disease Models Animal Graft vs Host Disease Humans Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Mice Mutant Strains Phosphoinositide-3 Kinase Inhibitors Scleroderma Localized T-Lymphocytes Helper-Inducer