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Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 15, 2020
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins...
HCMV Antivirals and Strategies to Target the Latent Reservoir.
A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes.
Apoptosis human cytomegalovirus latency long non-coding RNA Oxidative Stress Reactive Oxygen Species antioxidants Apoptosis Cells Cultured Cytomegalovirus Humans Lipopolysaccharide Receptors Mitochondria Monocytes Mutation Oxidative Stress RNA Long Noncoding RNA Viral Reactive Oxygen Species Virus Latency
A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes
Long non-coding RNA β2.7 is the most highly transcribed viral gene during latent human cytomegalovirus (HCMV) infection. However, as yet, no function has ever been ascribed to β2.7 during HCMV latency. Here we show that...
Human Cytomegalovirus Interleukin 10 Homologs
Emma Poole, Tainan Cerqueira Neves, Martha Trindade Oliveira, John Sinclair, Maria Cristina Carlan da Silva
Jul 20, 2020
Human Cytomegalovirus (HCMV) can cause a variety of health disorders that can lead to death in immunocompromised individuals and neonates. The HCMV lifecycle comprises both a lytic (productive) and a latent (non-productive)...
Advances in the treatment of cytomegalovirus.
antivirals human cytomegalovirus Infection latency vaccines Antiviral Agents Cytomegalovirus Cytomegalovirus Infections Cytomegalovirus Vaccines Drug development Early Diagnosis Hematopoietic Stem Cell Transplantation Humans Immunity Cellular Immunoglobulins Immunosuppression Therapy Infant Newborn Organ Transplantation Perinatal Care Virus Latency
An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation.
Emma Poole, Christopher JZ Huang, Jessica Forbester, Miri Shnayder, Aharon Nachshon, Baraa Kweider, Anna Basaj, Daniel Smith, Sarah Elizabeth Jackson, Bin Liu, Joy Shih, Fedir N Kiskin, K Roche, E Murphy, Mark R Wills, Nicholas W Morrell, Gordon Dougan, Noam Stern-Ginossar, Amer A Rana, John Sinclair
Sep 16, 2019
Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be...
Human Cytomegalovirus Interleukin 10 Homologs
Emma Poole, Tainan Cerqueira Neves, Martha Trindade Oliveira, John Sinclair, Maria Cristina Carlan da Silva
Jun 23, 2020
Human Cytomegalovirus (HCMV) can cause a variety of health disorders that can lead to death in immunocompromised individuals and neonates. The HCMV lifecycle comprises both a lytic (productive) and a latent (non-productive)...
Human cytomegalovirus protein pUL36
Alice Fletcher-Etherington, Luis Nobre, Katie Nightingale, Robin Antrobus, Jenna Nichols, Andrew J Davison, Richard J Stanton, Michael P Weekes
Jul 09, 2020
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of intrinsic, innate, and adaptive viral immune evasion. Here, we employed multiplexed tandem mass tag-based proteomics to characterize host proteins...
Human Cytomegalovirus Long Non-coding RNA1.2 Suppresses Extracellular Release of the Pro-inflammatory Cytokine IL-6 by Blocking NF-κB Activation.
Betty Lau, Karen Kerr, Quan Gu, Katie Nightingale, Robin Antrobus, Nicolás M Suárez, Richard J Stanton, Eddie CY Wang, Michael P Weekes, Andrew J Davison
Sep 09, 2020
Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and...
Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations.
Timokratis Karamitros, Bonnie van Wilgenburg, Mark Wills, Paul Klenerman, Gkikas Magiorkinis
Nov 06, 2018
BACKGROUND: Human cytomegalovirus (HCMV) has a double-stranded DNA genome of approximately 235 Kbp that is structurally complex including extended GC-rich repeated regions. Genomic recombination events are frequent in HCMV...
HCMV Antivirals and Strategies to Target the Latent Reservoir
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage. However, HCMV...
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions.
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 29, 2020
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins...
Latent Cytomegalovirus-Driven Recruitment of Activated CD4+ T Cells Promotes Virus Reactivation
Sarah E. Jackson, Kevin C. Chen, Ian J. Groves, George X. Sedikides, Amar Gandhi, Charlotte J. Houldcroft, Emma L. Poole, Inmaculada Montanuy, Gavin M. Mason, Georgina Okecha, Matthew B. Reeves, John H. Sinclair, Mark R. Wills
Apr 26, 2021
Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but persists for the lifetime of the host, in part due to its ability to establish a latent infection in cells of the myeloid lineage. HCMV has...
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex.
Katie Nightingale, Martin Potts, Leah M Hunter, Ceri A Fielding, Cassie M Zerbe, Alice Fletcher-Etherington, Luis Nobre, Eddie CY Wang, Blair L Strang, Jack W Houghton, Robin Antrobus, Nicolas M Suarez, Jenna Nichols, Andrew J Davison, Richard J Stanton, Michael P Weekes
Mar 05, 2022
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate, and adaptive immunity. We have employed two orthogonal multiplexed tandem mass tag-based proteomic...
Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells
Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo.
Emma Poole, Jatinder K Juss, Benjamin Krishna, Jurgen Herre, Edwin R Chilvers, John Sinclair
Jun 01, 2015
Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination.
Juliana Cudini, Sunando Roy, Charlotte J Houldcroft, Josephine M Bryant, Daniel P Depledge, Helena Tutill, Paul Veys, Rachel Williams, Austen JJ Worth, Asif U Tamuri, Richard A Goldstein, Judith Breuer
Feb 23, 2019
Diversity human cytomegalovirus Recombination superinfection whole genome sequencing Base Sequence Child Child Preschool Cytomegalovirus Cytomegalovirus Infections DNA Viral Female genetic variation Genome Human Genome Viral Haplotypes High-Throughput Nucleotide Sequencing Humans Immunocompromised Host Infant Infant Newborn Male Recombination Genetic Sequence Analysis DNA Superinfection
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.
Eddie CY Wang, Mariana Pjechova, Katie Nightingale, Virginia-Maria Vlahava, Mihil Patel, Eva Ruckova, Simone K Forbes, Luis Nobre, Robin Antrobus, Dawn Roberts, Ceri A Fielding, Sepehr Seirafian, James Davies, Isa Murrell, Betty Lau, Gavin S Wilkie, Nicolás M Suárez, Richard J Stanton, Borivoj Vojtesek, Andrew Davison, Paul J Lehner, Michael P Weekes, Gavin WG Wilkinson, Peter Tomasec
Jul 05, 2018
CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded gene that inhibits CD58 surface...
A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells.
Emma Poole, Maria Cristina Carlan da Silva, Chris Huang, Marianne Perera, Sarah Jackson, Ian J Groves, Mark Wills, Amer Rana, John Sinclair
May 05, 2021
Human cytomegalovirus (HCMV) presents a major health burden in the immunocompromised and in stem cell transplant medicine. A lack of understanding about the mechanisms of HCMV latency in undifferentiated CD34+ stem cells, and...
Human Cytomegalovirus Long Non-coding RNA1.2 Suppresses Extracellular Release of the Pro-inflammatory Cytokine IL-6 by Blocking NF-κB Activation
Betty Lau, Karen Kerr, Quan Gu, Katie Nightingale, Robin Antrobus, Nicolás M. Suárez, Richard J. Stanton, Eddie C. Y. Wang, Michael P. Weekes, Andrew J. Davison
Aug 05, 2020
Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and...
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