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Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease.
Rasa Elmentaite, Alexander DB Ross, Kenny Roberts, Kylie R James, Daniel Ortmann, Tomás Gomes, Komal Nayak, Liz Tuck, Sophie Pritchard, Omer Ali Bayraktar, Robert Heuschkel, Ludovic Vallier, Sarah A Teichmann, Matthias Zilbauer
Dec 10, 2020
Human gut development requires the orchestrated interaction of differentiating cell types. Here, we generate an in-depth single-cell map of the developing human intestine at 6-10 weeks post-conception. Our analysis reveals the...
human fetal gut development inflammatory bowel disease intestinal organoids intestinal stem cells pediatric Crohn's disease single-cell RNA sequencing villus formation Adolescent Cells Cultured Child Crohn Disease Humans Intestinal Mucosa RNA-seq Receptors G-Protein-Coupled Single-Cell Analysis Transcription Factors Transcriptome