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VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function.
Thomas Briston, Jenna M Stephen, Luke W Thomas, Cinzia Esposito, Yuen-Li Chung, Saiful E Syafruddin, Mark Turmaine, Lucas A Maddalena, Basma Greef, Gyorgy Szabadkai, Patrick H Maxwell, Sakari Vanharanta, Margaret Ashcroft
Nov 16, 2018
Genetic approaches to understand cellular responses to oxygen availability.
Oxygen-sensing mechanisms have evolved to allow organisms to respond and adapt to oxygen availability. In metazoans, oxygen-sensing is predominantly mediated by the hypoxia inducible factors (HIFs). These transcription factors...
Mannose binding lectin is hydroxylated by collagen prolyl-4-hydroxylase and inhibited by some PHD inhibitors
FG-4592 HEK293 Cells PHD inhibitors chronic kidney disease collagen prolyl-4-hydroxylase hypoxia inducible factor mannose binding lectin post-translational Protein Processing renal anemia vadadustat molidustat Collagen Hypoxia-Inducible Factor-Proline Dioxygenases Procollagen-Proline Dioxygenase Prolyl Hydroxylases Prolyl-Hydroxylase Inhibitors
Role of VHL, HIF1A and SDH on the expression of miR-210
A Merlo, C Bernardo-Castiñeira, I Sáenz-de-Santa-María, AS Pitiot, M Balbín, A Astudillo, N Valdés, B Scola, R Del Toro, S Mendez-Ferrer, JI Piruat, C Suarez, M-D Chiara
Aug 16, 2017
The hypoxia-inducible factor 1α (HIF-1α) and its microRNA target, miR-210, are candidate tumor-drivers of metabolic reprogramming in cancer. Neuroendocrine neoplasms such as paragangliomas (PGLs) are particularly appealing for...