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Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor
S Kiriakidis, SS Hoer, N Burrows, G Biddlecome, MN Khan, CC Thinnes, CJ Schofield, N Rogers, M Botto, E Paleolog, PH Maxwell
May 24, 2017
Notch Signaling and Cross-Talk in Hypoxia
Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O2) homeostasis, adjusting convective O2 delivery and utilization (i.e., metabolism). Human populations have been exposed to...