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Targeting Mitochondrial Metabolism in Neuroinflammation
The lack of effective treatment options for chronic neurological conditions, such as multiple sclerosis (MS), highlights the need to re-evaluate disease pathophysiology in the process of identifying novel therapeutic targets....
immune metabolism MACROPHAGES Microglia Mitochondria Neuroinflammation progressive multiple sclerosis Central Nervous System Crotonates Dimethyl Fumarate Electron Transport Glymphatic System Humans Hydroxybutyrates Immunity Innate Metabolic Networks and Pathways Microglia Mitochondria Molecular Targeted Therapy Mononuclear Phagocyte System Multiple Sclerosis Chronic Progressive Neurodegenerative Diseases Nitriles Signal Transduction Stem Cell Transplantation Toluidines
Metabolic reprograming of mononuclear phagocytes in progressive multiple sclerosis.
Gillian Margaret Tannahill, Nunzio Iraci, Edoardo Gaude, Christian Frezza, Stefano Pluchino
Aug 28, 2020
UNLABELLED: Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Accumulation of brain damage in progressive MS is partly the result of mononuclear phagocytes (MPs) attacking...