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<i>In vitro - in vivo </i>relations for the parenteral liposomal formulation of Amphotericin B
In vitro release testing is a useful tool for the quality control of controlled release parenteral formulations, but in vitro release test conditions that reflect or are able to predict the in vivo performance are...
<i>In vitro in vivo r</i>elations for the parenteral liposomal formulation of Amphotericin B
There is limited information on how to perform in vitro release tests for intravenously administered parenteral formulations and how to relate the in vitro release with an in vivo pharmacokinetic parameter after the...
Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.
Berna Sozen, Andy L Cox, Joachim De Jonghe, Min Bao, Florian Hollfelder, David M Glover, Magdalena Zernicka-Goetz
Dec 19, 2019
Mammalian blastocysts comprise three distinct cell lineages essential for development beyond implantation: the pluripotent epiblast, which generates the future embryo, and surrounding it the extra-embryonic primitive endoderm...
Blastoid development Embryo Endoderm Extended pluripotency in vitro preimplantation Stem Cells trophoblast Animals Blastocyst Cell Differentiation Cell Lineage Embryo Implantation Embryo Mammalian Embryonic Development Endoderm Gene Expression Regulation Developmental Mice Mouse embryonic stem cells
Dextran 500 Improves Recovery of Inflammatory Markers
Susan Giorgi-Coll, Eric Peter Thelin, Caroline Lindblad, Tamara Tajsic, Keri LH Carpenter, Peter JA Hutchinson, Adel Helmy
Jul 18, 2019
A Continuous-Flow Model for in vitro Cultivation of Mixed Microbial Populations Associated With Cystic Fibrosis Airway Infections.
The airways of people with cystic fibrosis (CF) provide a nutrient-rich environment which favours colonisation by a variety of bacteria and fungi. Although the dominant pathogen associated with CF airway infections is...
Recapitulation of polymicrobial communities associated with cystic fibrosis airway infections
The airways of persons with cystic fibrosis are prone to infection by a diverse and dynamic polymicrobial consortium. Currently, no models exist that permit recapitulation of this consortium within the laboratory. Such microbial...
Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model.
Eric Peter Thelin, Claire E Hall, Kunal Gupta, Keri LH Carpenter, Siddharthan Chandran, Peter J Hutchinson, Rickie Patani, Adel Helmy
Jun 05, 2018
Cytokine mediated inflammation likely plays an important role in secondary pathology after traumatic brain injury (TBI). The aim of this study was to elucidate secondary cytokine responses in an in vitro enriched (>80%) human...
A Continuous-Flow Model for in vitro Cultivation of Mixed Microbial Populations Associated With Cystic Fibrosis Airway Infections
The airways of people with cystic fibrosis (CF) provide a nutrient-rich environment which favours colonisation by a variety of bacteria and fungi. Although the dominant pathogen associated with CF airway infections is...
Organic transistor platform with integrated microfluidics for in-line multi-parametric in vitro cell monitoring.
Vincenzo F Curto, Bastien Marchiori, Adel Hama, Anna-Maria Pappa, Magali P Ferro, Marcel Braendlein, Jonathan Rivnay, Michel Fiocchi, George G Malliaras, Marc Ramuz, Róisín M Owens
Jun 17, 2019
Future drug discovery and toxicology testing could benefit significantly from more predictive and multi-parametric readouts from in vitro models. Despite the recent advances in the field of microfluidics, and more recently...
<i>In vitro - in vivo </i>relations for the parenteral liposomal formulation of Amphotericin B
In vitro release testing is a useful tool for the quality control of controlled release parenteral formulations, but in vitro release test conditions that reflect or are able to predict the in vivo performance are...
A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity.
Chiara Barberio, Aimee Withers, Yash Mishra, Pierre-Olivier Couraud, Ignacio A Romero, Babette Weksler, Róisín M Owens
Dec 19, 2022
Disease modelling in human organoids.
The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms...
<i>In vitro in vivo r</i>elations for the parenteral liposomal formulation of Amphotericin B
There is limited information on how to perform in vitro release tests for intravenously administered parenteral formulations and how to relate the in vitro release with an in vivo pharmacokinetic parameter after the...
Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma.
Eric Peter Thelin, Claire E Hall, Giulia E Tyzack, Arvid Frostell, Susan Giorgi-Coll, Aftab Alam, Keri LH Carpenter, Jamie Mitchell, Tamara Tajsic, Peter J Hutchinson, Rickie Patani, Adel Helmy
Sep 27, 2019