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Clinical frailty independently predicts early mortality after ischaemic stroke.
Nicholas R Evans, Jasmine Wall, Benjaman To, Stephen J Wallis, Roman Romero-Ortuno, Elizabeth A Warburton
Dec 16, 2019
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N Christie, Shefeeq M Theparambil, Sean M Davidson, Frank Reimann, Stefan Trapp, Derek M Yellon, Alexander V Gourine
Jan 28, 2022
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments...
Brain capillaries Brain arterioles cerebral blood flow Glucagon-like peptide-1 Ischaemic stroke Middle cerebral artery occlusion Neuroprotection Remote ischaemic preconditioning Animals Arterioles Cerebrovascular Circulation Disease Models Animal Glucagon-Like Peptide-1 Receptor Hindlimb Incretins Infarction Middle Cerebral artery Ischemic preconditioning ischemic stroke Male Neuroprotective Agents Peptide Fragments Rats Sprague-Dawley Regional Blood Flow Vasodilation Vasodilator Agents
Predicting 10-year stroke mortality
Weronika A Szlachetka, Tiberiu A Pana, Mamas A Mamas, Joao H Bettencourt-Silva, Anthony K Metcalf, John F Potter, David J McLernon, Phyo K Myint
Jun 07, 2022
Predicting long-term stroke mortality is a clinically important and unmet need. We aimed to develop and internally validate a 10-year ischaemic stroke mortality prediction score. In this UK cohort study, 10,366 patients with...
Cerebrovascular disease Ischaemic stroke long-term mortality Prediction score Prognosis Aged Aged 80 and over Atrial fibrillation Brain Ischemia Cohort Studies Coronary Disease Female Heart Failure Humans Hypertension ischemic stroke Male Nomograms peripheral vascular diseases Pulmonary Disease Chronic Obstructive Risk Factors stroke
The Histone Deacetylase 9 Stroke-Risk Variant Promotes Apoptosis and Inflammation in a Human iPSC-Derived Smooth Muscle Cells Model.
Alessandra Granata, Ioannis Kasioulis, Felipe Serrano, James D Cooper, Matthew Traylor, Sanjay Sinha, Hugh S Markus
Apr 13, 2022
A common variant in the Histone Deacetylase 9 (HDAC9) gene is the strongest genetic risk for large-vessel stroke, and HDAC9 offers a novel target for therapeutic modulation. However, the mechanisms linking the HDAC9 variant with...
Leveraging Genetic Data to Elucidate the Relationship Between COVID-19 and Ischemic Stroke.
Verena Zuber, Alan Cameron, Evangelos P Myserlis, Leonardo Bottolo, Israel Fernandez-Cadenas, Stephen Burgess, Christopher D Anderson, Jesse Dawson, Dipender Gill
Sep 30, 2021
Background The relationship between COVID-19 and ischemic stroke is poorly understood due to potential unmeasured confounding and reverse causation. We aimed to leverage genetic data to triangulate reported associations. Methods...
COVID‐19 Mendelian randomization cross‐trait linkage disequilibrium score regression ischemic stroke Body Mass Index Brain Ischemia C-Reactive Protein covid-19 Genome-Wide Association Study Humans Inflammation ischemic stroke Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Smoking
Genetically Predicted Type 2 Diabetes Mellitus Liability, Glycated Hemoglobin and Cardiovascular Diseases
Bowen Liu, Amy M Mason, Luanluan Sun, Emanuele Di Angelantonio, Dipender Gill, Stephen Burgess
Oct 21, 2021
average blood glucose Cardiovascular Diseases hemoglobin A1c Mendelian randomization type 2 diabetes mellitus aortic valve stenosis Cardiovascular Diseases Coronary Artery Disease Diabetes mellitus Type 2 Female Genetic Association Studies Genetic Predisposition to Disease genetic variation Glycated Hemoglobin Heart Failure Humans ischemic stroke Male Mendelian Randomization Analysis Middle Aged peripheral vascular diseases stroke
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Amin Mottahedin, Hiran A Prag, Andreas Dannhorn, Richard Mair, Christina Schmidt, Ming Yang, Annabel Sorby-Adams, Jordan J Lee, Nils Burger, Duvaraka Kulaveerasingam, Margaret M Huang, Stefano Pluchino, Luca Peruzzotti-Jametti, Richard Goodwin, Christian Frezza, Michael P Murphy, Thomas Krieg
Feb 12, 2023
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jun 06, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study.
Carotid Intima-Media Thickness Coronary Artery Disease Inflammation Mendelian randomization Periodontitis Risk factor stroke Atherosclerosis Brain Ischemia Carotid Intima-Media Thickness Coronary Artery Disease Genome-Wide Association Study Humans ischemic stroke Mendelian Randomization Analysis Periodontitis Polymorphism Single Nucleotide Risk Factors stroke
Computational drug repositioning for ischemic stroke
Background: A comprehensive approach to drug repositioning will be required to overcome translational hurdles and identify more neuroprotective drugs. Results & methods: Gene Set Enrichment Analysis was applied to identify...
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G Boutelle, Eszter Farkas, Jens P Dreier, Martin Fabricius, C William Shuttleworth, Andrew Carlson
Jul 29, 2019
The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, "What should a clinician do when spreading depolarizations are...
Cortical Spreading Depression Electroencephalography Intracerebral hemorrhage ischemic stroke outcome Subarachnoid Hemorrhage Traumatic brain injury Brain Injuries Traumatic Cortical Spreading Depression Electrocorticography Electroencephalography Excitatory Amino Acid Antagonists Humans Ketamine Outcome Assessment Health Care Precision Medicine stroke Subarachnoid Hemorrhage
Metabolic Traits and Stroke Risk in Individuals of African Ancestry
Segun Fatumo, Ville Karhunen, Tinashe Chikowore, Toure Sounkou, Brenda Udosen, Chisom Ezenwa, Mariam Nakabuye, Opeyemi Soremekun, Iyas Daghlas, David K Ryan, Amybel Taylor, Amy M Mason, Scott M Damrauer, Marijana Vujkovic, Keith L Keene, Myriam Fornage, Marjo-Riitta Järvelin, Stephen Burgess, Dipender Gill
Mar 31, 2021
BACKGROUND AND PURPOSE: Metabolic traits affect ischemic stroke (IS) risk, but the degree to which this varies across different ethnic ancestries is not known. Our aim was to apply Mendelian randomization to investigate the...
Cholesterol ischemic stroke Lipid Mortality Risk factor Adult Black People Cholesterol HDL Cholesterol LDL Diabetes mellitus Type 2 Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Risk Factors stroke Triglycerides United Kingdom
Genetic Risk, Muscle Strength, and Incident Stroke
Youngwon Kim, Semi Hwang, Stephen J Sharp, Shan Luo, Shiu Lun Au Yeung, Craig C Teerlink
Jul 12, 2021
OBJECTIVE: To examine the associations of muscle strength and genetic risk for stroke with stroke incidence. PARTICIPANTS AND METHODS: We included 284,767 white British participants of UK Biobank without genetic relatedness and...
Sepsis-driven atrial fibrillation and ischaemic stroke. Is there enough evidence to recommend anticoagulation?
Isuru Induruwa, Eleanor Hennebry, James Hennebry, Mrinal Thakur, Elizabeth A Warburton, Kayvan Khadjooi
Oct 19, 2021
Sepsis can lead to cardiac arrhythmias, of which the most common is atrial fibrillation (AF). Sepsis is associated with up to a six-fold higher risk of developing AF, where it occurs most commonly in the first 3 days of hospital...
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease
Marios K Georgakis, Eric L Harshfield, Rainer Malik, Nora Franceschini, Claudia Langenberg, Nicholas J Wareham, Hugh S Markus, Martin Dichgans
Oct 29, 2020
Atrophy Blood Glucose Brain Carotid Artery Diseases cerebral hemorrhage Cerebrovascular Disorders Diabetes mellitus Type 2 Genetic Predisposition to Disease Glycated Hemoglobin Humans Hyperglycemia Insulin Resistance Insulin-Secreting Cells ischemic stroke Mendelian Randomization Analysis white matter
Diversity of Reactive Astrogliosis in CNS Pathology
Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as "reactive...
A meta-analysis of extended ECG monitoring in detection of atrial fibrillation in patients with cryptogenic stroke.
Haowen Jiang, Shyn Yi Tan, Jeremy King Wang, Jiaqi Li, Tian Ming Tu, Vern Hsen Tan, Colin Yeo
Oct 30, 2022
OBJECTIVE: The aim of this systematic review is to evaluate the various modalities available for extended ECG monitoring in the detection of atrial fibrillation (AF) following a cryptogenic stroke. METHODS: MEDLINE (Ovid)...
Stroke genetics informs drug discovery and risk prediction across ancestries.
Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C Posner, Frederick K Kamanu, Masaru Koido, Quentin Le Grand, Mingyang Shi, Yunye He, Marios K Georgakis, Ilana Caro, Kristi Krebs, Yi-Ching Liaw, Felix C Vaura, Kuang Lin, Bendik Slagsvold Winsvold, Vinodh Srinivasasainagendra, Livia Parodi, Hee-Joon Bae, Ganesh Chauhan, Michael R Chong, Liisa Tomppo, Rufus Akinyemi, Gennady V Roshchupkin, Naomi Habib, Yon Ho Jee, Jesper Qvist Thomassen, Vida Abedi, Jara Cárcel-Márquez, Marianne Nygaard, Hampton L Leonard, Chaojie Yang, Ekaterina Yonova-Doing, Maria J Knol, Adam J Lewis, Renae L Judy, Tetsuro Ago, Philippe Amouyel, Nicole D Armstrong, Mark K Bakker, Traci M Bartz, David A Bennett, Joshua C Bis, Constance Bordes, Sigrid Børte, Anael Cain, Paul M Ridker, Kelly Cho, Zhengming Chen, Carlos Cruchaga, John W Cole, Phil L de Jager, Rafael de Cid, Matthias Endres, Leslie E Ferreira, Mirjam I Geerlings, Natalie C Gasca, Vilmundur Gudnason, Jun Hata, Jing He, Alicia K Heath, Yuk-Lam Ho, Aki S Havulinna, Jemma C Hopewell, Hyacinth I Hyacinth, Michael Inouye, Mina A Jacob, Christina E Jeon, Christina Jern, Masahiro Kamouchi, Keith L Keene, Takanari Kitazono, Steven J Kittner, Takahiro Konuma, Amit Kumar, Paul Lacaze, Lenore J Launer, Keon-Joo Lee, Kaido Lepik, Jiang Li, Liming Li, Ani Manichaikul, Hugh S Markus, Nicholas A Marston, Thomas Meitinger, Braxton D Mitchell, Felipe A Montellano, Takayuki Morisaki, Thomas H Mosley, Mike A Nalls, Børge G Nordestgaard, Martin J O'Donnell, Yukinori Okada, N Charlotte Onland-Moret, Bruce Ovbiagele, Annette Peters, Bruce M Psaty, Stephen S Rich, Jonathan Rosand, Marc S Sabatine, Ralph L Sacco, Danish Saleheen, Else Charlotte Sandset, Veikko Salomaa, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia L Satizabal, Carsten O Schmidt, Atsushi Shimizu, Nicholas L Smith, Kelly L Sloane, Yoichi Sutoh, Yan V Sun, Kozo Tanno, Steffen Tiedt, Turgut Tatlisumak, Nuria P Torres-Aguila, Hemant K Tiwari, David-Alexandre Trégouët, Stella Trompet, Anil Man Tuladhar, Anne Tybjaerg-Hansen, Marion van Vugt, Riina Vibo, Shefali S Verma, Kerri L Wiggins, Patrik Wennberg, Daniel Woo, Peter WF Wilson, Huichun Xu, Qiong Yang, Kyungheon Yoon, COMPASS Consortium, INVENT Consortium, Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group, Estonian Biobank, PRECISE4Q Consortium, FinnGen Consortium, NINDS Stroke Genetics Network (SiGN), MEGASTROKE Consortium, SIREN Consortium, China Kadoorie Biobank Collaborative Group, VA Million Veteran Program, International Stroke Genetics Consortium (ISGC), Biobank Japan, CHARGE consortium, GIGASTROKE Consortium, Iona Y Millwood, Christian Gieger, Toshiharu Ninomiya, Hans J Grabe, J Wouter Jukema, Ina L Rissanen, Daniel Strbian, Young Jin Kim, Pei-Hsin Chen, Ernst Mayerhofer, Joanna MM Howson, Marguerite R Irvin, Hieab Adams, Sylvia Wassertheil-Smoller, Kaare Christensen, Mohammad A Ikram, Tatjana Rundek, Bradford B Worrall, G Mark Lathrop, Moeen Riaz, Eleanor M Simonsick, Janika Kõrv, Paulo HC França, Ramin Zand, Kameshwar Prasad, Ruth Frikke-Schmidt, Frank-Erik de Leeuw, Thomas Liman, Karl Georg Haeusler, Ynte M Ruigrok, Peter Ulrich Heuschmann, WT Longstreth, Keum Ji Jung, Lisa Bastarache, Guillaume Paré, Scott M Damrauer, Daniel I Chasman, Jerome I Rotter, Christopher D Anderson, John-Anker Zwart, Teemu J Niiranen, Myriam Fornage, Yung-Po Liaw, Sudha Seshadri, Israel Fernández-Cadenas, Robin G Walters, Christian T Ruff, Mayowa O Owolabi, Jennifer E Huffman, Lili Milani, Yoichiro Kamatani, Martin Dichgans, Stephanie Debette
Nov 15, 2022
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of...
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jul 22, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
The relationship between the platelet to leukocyte ratio and mechanical thrombectomy outcomes in acute ischemic stroke patients.
BACKGROUND AND PURPOSE: The predictive effect of blood cell ratio on ischemic event has been widely confirmed. Whether PWR and PNR can assess the risk of endovascular treatment (EVT) is largely unclear. This study aimed to...
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
J Rodhe, MA Burguillos, RM de Pablos, E Kavanagh, A Persson, E Englund, T Deierborg, JL Venero, B Joseph
Apr 27, 2017
Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion.
Julius V Emmrich, Sohail Ejaz, David J Williamson, Young T Hong, Sergey Sitnikov, Tim D Fryer, Franklin I Aigbirhio, Heike Wulff, Jean-Claude Baron
Jan 09, 2020
Although early reperfusion after stroke salvages the still-viable ischemic tissue, peri-infarct selective neuronal loss (SNL) can cause sensorimotor deficits (SMD). We designed a longitudinal protocol to assess the effects of...
A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke.
Alexandra Lucaciu, Hannah Kuhn, Sandra Trautmann, Nerea Ferreirós, Helmuth Steinmetz, Josef Pfeilschifter, Robert Brunkhorst, Waltraud Pfeilschifter, Julien Subburayalu, Rajkumar Vutukuri
Aug 29, 2020
Emerging evidence suggests a complex relationship between sphingosine 1-phosphate (S1P) signaling and stroke. Here, we show the kinetics of S1P in the acute phase of ischemic stroke and highlight accompanying changes in immune...
Ceramides fingolimod regulatory T helper cells sphingosine 1-phosphate sphingosine 1-phosphate receptor sphingosine kinase stroke Animals Brain Disease Models Animal ischemic stroke Lysophospholipids Male Mice Mice Inbred C57BL Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory
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