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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Christopher AG Booth, Nikolaos Barkas, Wen Hao Neo, Hanane Boukarabila, Elizabeth J Soilleux, George Giotopoulos, Noushin Farnoud, Alice Giustacchini, Neil Ashley, Joana Carrelha, Lauren Jamieson, Deborah Atkinson, Tiphaine Bouriez-Jones, Rab K Prinjha, Thomas A Milne, David T Teachey, Elli Papaemmanuil, Brian JP Huntly, Sten Eirik W Jacobsen, Adam J Mead
Feb 12, 2019
Lympho-myeloid restricted early thymic progenitors (ETPs) are postulated to be the cell of origin for ETP leukemias, a therapy-resistant leukemia associated with frequent co-occurrence of EZH2 and RUNX1 inactivating mutations...
BET inhibition EZH2 FLT3-ITD RUNX1 early thymic progenitor leukemia early thymic progenitors leukemia propagating cells leukemic stem cells Animals Core Binding Factor Alpha 2 Subunit Enhancer of Zeste Homolog 2 Protein Gene Expression Regulation Leukemic Leukemia Myeloid Acute Mice Knockout Mutation Myeloid Cells Signal Transduction Stem Cells