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Cover Image for Naive stem cell blastocyst model captures human embryo lineage segregation. View Article
Naive stem cell blastocyst model captures human embryo lineage segregation.
Ayaka Yanagida, Daniel Spindlow, Jennifer Nichols, Anish Dattani, Austin Smith, Ge Guo
May 14, 2021
Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and hypoblast. Here we describe a human embryo model (blastoid) generated by self-organization. Brief induction of trophectoderm leads to...
Blastocyst Embryonic Stem Cells Epiblast Human embryo hypoblast lineage segregation Pluripotency Self-organization trophoblast Blastocyst Cell Differentiation Cell Lineage Embryo Mammalian Germ Layers Humans Stem Cells
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