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Viroplasms
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers...
Crispr-Csy4 Genome Editing Nsp2 Nsp5 liquid-liquid phase separation Protein-Rna Condensates Replication Cycle Reverse Genetics Rotavirus Viroplasm Animals Capsid Proteins Cytoplasm Cytosol Humans Phosphorylation RNA-Binding Proteins Rotavirus Rotavirus Infections Viral Nonstructural Proteins Viral Replication Compartments Virus Assembly Virus Replication
Recent Advances in Microgels
Yufan Xu, Hongjia Zhu, Akhila Denduluri, Yangteng Ou, Nadia A Erkamp, Runzhang Qi, Yi Shen, Tuomas PJ Knowles
Jul 05, 2022
Viroplasms
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers...
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus.
Hongjia Zhu, Masako Narita, Jerelle A Joseph, Georg Krainer, William E Arter, Ioana Olan, Kadi L Saar, Niklas Ermann, Jorge R Espinosa, Yi Shen, Masami Ando Kuri, Runzhang Qi, Timothy J Welsh, Rosana Collepardo-Guevara, Masashi Narita, Tuomas PJ Knowles
Nov 30, 2022
Viroplasms
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers...
Reverse Genetics Rotavirus Replication Cycle Nsp2 liquid-liquid phase separation Viroplasm Protein-Rna Condensates Nsp5 Crispr-Csy4 Genome Editing
Published by: Viruses
Liquid-Liquid Phase-Separated Systems from Reversible Gel-Sol Transition of Protein Microgels.
Yufan Xu, Runzhang Qi, Hongjia Zhu, Bing Li, Yi Shen, Georg Krainer, David Klenerman, Tuomas PJ Knowles
Apr 29, 2021
Liquid-liquid phase-separated biomolecular systems are increasingly recognized as key components in the intracellular milieu where they provide spatial organization to the cytoplasm and the nucleoplasm. The widespread use of...