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Prevalence and Factors Associated With Liver Fibrosis Among Adult HIV-Infected Patients Attending Urban and Rural Care Clinics in Uganda.
Clara Wekesa, Gregory D Kirk, Jim Aizire, Eve-Marie Benson, Alex Karabarinde, Rosalind Parkes-Ratanshi, Ponsiano Ocama
Nov 04, 2020
BACKGROUND: Liver fibrosis is common among HIV-infected patients. Risk factors vary by location. Understanding this variation may inform prevention strategies. We compared the prevalence and correlates of liver fibrosis among...
Indirect serum biomarkers perform sub optimally in screening for significant liver fibrosis among HIV-infected and uninfected adults in Uganda.
INTRODUCTION: Indirect serum bio-markers present an acceptable noninvasive and cheap alternative for screening of significant liver fibrosis (SLF). Evaluation of their use in resource limited settings is important to determine...
Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.
Ross Dobie, John R Wilson-Kanamori, Beth EP Henderson, James R Smith, Kylie P Matchett, Jordan R Portman, Karolina Wallenborg, Simone Picelli, Anna Zagorska, Swetha V Pendem, Thomas E Hudson, Minnie M Wu, Grant R Budas, David G Breckenridge, Ewen M Harrison, Damian J Mole, Stephen J Wigmore, Prakash Ramachandran, Chris P Ponting, Sarah A Teichmann, John C Marioni, Neil C Henderson
Dec 19, 2019
Iterative liver injury results in progressive fibrosis disrupting hepatic architecture, regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of pathological matrix during fibrosis and are...