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Key contribution of eIF4H-mediated translational control in tumor promotion.
Charlotte Vaysse, Céline Philippe, Yvan Martineau, Cathy Quelen, Corinne Hieblot, Claire Renaud, Yvan Nicaise, Aurore Desquesnes, Maria Pannese, Thomas Filleron, Ghislaine Escourrou, Malcolm Lawson, Robert C Rintoul, Marie Bernadette Delisle, Stéphane Pyronnet, Pierre Brousset, Hervé Prats, Christian Touriol
Sep 05, 2018
Dysregulated expression of translation initiation factors has been associated with carcinogenesis, but underlying mechanisms remains to be fully understood. Here we show that eIF4H (eukaryotic translation initiation factor 4H)...
IRES chemoresistance eIF4H helicase lung carcinoma Translation Initiation Factor Animals Antineoplastic Agents Apoptosis Blotting Western Cell Cycle Cell Line Tumor Cell Proliferation cisplatin Etoposide Eukaryotic Initiation Factors Female Gene Expression Regulation Neoplastic HeLa Cells Humans Lung Neoplasms Male Mice Mice Nude NIH 3T3 Cells Protein Biosynthesis RNA Interference RNAi Therapeutics Reverse Transcriptase Polymerase Chain Reaction Tumor Burden Xenograft Model Antitumor Assays