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Small cargoes pass through synthetically glued Golgi stacks.
Julia Dancourt, Hong Zheng, Francesca Bottanelli, Edward S Allgeyer, Joerg Bewersdorf, Morven Graham, Xinran Liu, James E Rothman, Grégory Lavieu
Apr 15, 2019
How are proteins transported across the stacked cisternae of the Golgi apparatus? Do they stay within the cisterna while the latter matures and progresses in an anterograde manner, or do they navigate between the cisternae via...
Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes.
Daniel J Fazakerley, Sheyda Naghiloo, Rima Chaudhuri, Françoise Koumanov, James G Burchfield, Kristen C Thomas, James R Krycer, Matthew J Prior, Ben L Parker, Beverley A Murrow, Jacqueline Stöckli, Christopher C Meoli, Geoffrey D Holman, David E James
Aug 28, 2020
Insulin signaling augments glucose transport by regulating glucose transporter 4 (GLUT4) trafficking from specialized intracellular compartments, termed GLUT4 storage vesicles (GSVs), to the plasma membrane. Proteomic analysis...
Structural basis for the binding of tryptophan-based motifs by δ-COP.
Richard J Suckling, Pak Phi Poon, Sophie M Travis, Irina V Majoul, Frederick M Hughson, Philip R Evans, Rainer Duden, David J Owen
Oct 22, 2015
COPI coatomer membrane trafficking vesicle coat δ-COP μ homology domain-binding motifs Amino Acid Motifs COP-Coated Vesicles Calorimetry Indirect Cathepsin A Coatomer Protein DNA-Binding Proteins GTPase-Activating Proteins Protein Binding Protein Structure Tertiary Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Tryptophan
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.
Svetlana Saveljeva, Gavin W Sewell, Katharina Ramshorn, M Zaeem Cader, James A West, Simon Clare, Lea-Maxie Haag, Rodrigo Pereira de Almeida Rodrigues, Lukas W Unger, Ana Belén Iglesias-Romero, Lorraine M Holland, Christophe Bourges, Muhammad N Md-Ibrahim, James O Jones, Richard S Blumberg, James C Lee, Nicole C Kaneider, Trevor D Lawley, Allan Bradley, Gordon Dougan, Arthur Kaser
Feb 05, 2022
Still's disease, the paradigm of autoinflammation-cum-autoimmunity, predisposes for a cytokine storm with excessive T lymphocyte activation upon viral infection. Loss of function of the purine nucleoside enzyme FAMIN is the sole...
Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation.
Timothy K Soh, Colin TR Davies, Julia Muenzner, Leah M Hunter, Henry G Barrow, Viv Connor, Clément R Bouton, Cameron Smith, Edward Emmott, Robin Antrobus, Stephen C Graham, Michael P Weekes, Colin M Crump
Sep 16, 2020
Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time course of herpes simplex virus 1 (HSV-1)...