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Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells
Mesenchymal Stromal Cells (MSC) are multipotent cells characterized by self-renewal, multilineage differentiation, and immunomodulatory properties. To obtain a gene regulatory profile of human MSCs, we generated a compendium of...
Infrapatellar fat pad adipose-derived stem cells co-cultured with articular chondrocytes from osteoarthritis patients exhibit increased chondrogenic gene expression.
AIM: The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought...
The Influence of Ageing and Gender in Musculoskeletal Stem Cell.
BACKGROUND: Multipotent Mesenchymal Stromal Cells (MSCs) are the most common type of stem cell used in the regeneration of skeletal tissue. These cells have multipotent, angiogenic, paracrine, anti-fibrotic and immunological...
Ageing Gender mesenchymal stromal cells skeletal tissue stem cell tissue engineering. Age Factors Cell Differentiation Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Regeneration Sex Factors
Published by: Curr Stem Cell Res Ther
Infrapatellar fat pad adipose-derived stem cells co-cultured with articular chondrocytes from osteoarthritis patients exhibit increased chondrogenic gene expression.
AIM: The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought...
Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma
Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa
Mar 05, 2021
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal...
Chronological Age Affects MSC Senescence In Vitro—A Systematic Review
Konstantinos Kapetanos, Dimitrios Asimakopoulos, Neophytos Christodoulou, Antonia Vogt, Wasim Khan
Jul 28, 2021
The use of mesenchymal stromal cells (MSCs) in regenerative medicine and tissue engineering is well established, given their properties of self-renewal and differentiation. However, several studies have shown that these...
Promoter optimisation of lentiviral vectors for efficient insulin gene expression in canine mesenchymal stromal cells
Pratigya Gautam, Asha Recino, Robert D Foale, Jing Zhao, Shu Uin Gan, Maja Wallberg, Roy Calne, Andrew ML Lever
Oct 20, 2016
Diabetes gene therapy Insulin Lentivirus mesenchymal stromal cells Animals Bone Marrow Cells Cell Line Tumor Cells Cultured Dogs Gene Expression Gene Transfer Techniques Genetic Therapy Genetic Vectors HEK293 Cells Hepatocytes Humans Insulin Insulin-Secreting Cells Lentivirus Mesenchymal Stem Cells Proinsulin Promoter Regions Genetic
Autologous adipose tissue grafting for the management of the painful scar.
BACKGROUND AIMS: There is currently no definitive treatment for the painful scar. Autologous adipose tissue grafting (AATG) as a treatment option for scars has become increasingly popular and there is now an abundance of...
Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells.
Elena Sánchez-Luis, Andrea Joaquín-García, Francisco J Campos-Laborie, Fermín Sánchez-Guijo, Javier De Las Rivas
Jun 22, 2020
Mesenchymal Stromal Cells (MSC) are multipotent cells characterized by self-renewal, multilineage differentiation, and immunomodulatory properties. To obtain a gene regulatory profile of human MSCs, we generated a compendium of...
Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma.
Esperanza M Algarín, Dalia Quwaider, Francisco J Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M Ocio, Mercedes Garayoa
May 17, 2021
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal...
Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model.
Hareklea Markides, Karin J Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E Dixon, Robert H Morris, Martin Graves, Joshua Kaggie, Frances Henson, Alicia J El Haj
Feb 07, 2019
BACKGROUND: Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research efforts....
MRI mesenchymal stromal cells osteochondral Pre-clinical. Translational SPIONs tracking Animals Bone Marrow Cells Cell Differentiation Cell Survival Cell Tracking Ferric Compounds Knee Joint Magnetic Resonance Imaging Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Sheep Synovial Membrane
Chronological Age Affects MSC Senescence In Vitro-A Systematic Review.
Konstantinos Kapetanos, Dimitrios Asimakopoulos, Neophytos Christodoulou, Antonia Vogt, Wasim Khan
Sep 08, 2021
The use of mesenchymal stromal cells (MSCs) in regenerative medicine and tissue engineering is well established, given their properties of self-renewal and differentiation. However, several studies have shown that these...