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Results: 13
Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα.
James A Horscroft, Katie A O'Brien, Anna D Clark, Ross T Lindsay, Alice Strang Steel, Nathan EK Procter, Jules Devaux, Michael Frenneaux, Stephen DR Harridge, Andrew J Murray
Feb 27, 2019
Dietary inorganic nitrate prevents aspects of cardiac mitochondrial dysfunction induced by hypoxia, although the mechanism is not completely understood. In both heart and skeletal muscle, nitrate increases fatty acid oxidation...
Current Knowledge and Future Directions in Developing Strategies to Combat Pseudomonas aeruginosa Infection.
Stephen K Dolan
Jul 30, 2020
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis.
RATIONALE: Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and features of plaque instability, in part, through lipid-mediated oxidative DNA damage and telomere dysfunction. SIRT6 (Sirtuin 6) is a nuclear...
Atherosclerosis Inflammation metabolism Muscle Cells Telomere Animals Aorta Apolipoproteins E Atherosclerosis Cells Cultured Cellular Senescence Cytokines Histones Humans JNK Mitogen-Activated Protein Kinases Mice Mice Inbred C57BL Muscle Smooth Vascular Myocytes Smooth Muscle Sirtuins Telomere Homeostasis Tumor Suppressor p53-Binding Protein 1 Ubiquitin-Protein Ligases p38 Mitogen-Activated Protein Kinases
Mitochondrial DNA copy number variation across human cancers.
Ed Reznik, Martin L Miller, Yasin Şenbabaoğlu, Nadeem Riaz, Judy Sarungbam, Satish K Tickoo, Hikmat A Al-Ahmadie, William Lee, Venkatraman E Seshan, A Ari Hakimi, Chris Sander
Jan 24, 2018
Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number variation across 22 tumor types profiled by The Cancer Genome Atlas project. We...
Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes
Emanuele F Osimo, Benjamin I Perry, Rudolf N Cardinal, Mary-Ellen Lynall, Jonathan Lewis, Arti Kudchadkar, Graham K Murray, Jesus Perez, Peter B Jones, Golam M Khandaker
Sep 15, 2020
Approximately one third of patients presenting with a first episode of psychosis need long-term support, but there is a limited understanding of the sociodemographic or biological factors that predict this outcome. We used...
O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli.
Connor Sharp, Christine Boinett, Amy Cain, Nicholas G Housden, Sandip Kumar, Keith Turner, Julian Parkhill, Colin Kleanthous
Aug 20, 2019
The outer membrane of Gram-negative bacteria presents a significant barrier for molecules entering the cell. Nevertheless, colicins, which are antimicrobial proteins secreted by Escherichia coli, can target other E. coli cells...
bacteriocins cell envelope enteric bacteria outer membrane Anti-Bacterial Agents Colicins DNA Transposable Elements Drug Resistance Bacterial Gene Silencing metabolism Microarray Analysis Microbial Sensitivity Tests Mutagenesis Insertional O Antigens Phenotype Sequence Analysis DNA Uropathogenic Escherichia coli
Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury.
Alex M Dickens, Jussi P Posti, Riikka SK Takala, Henna Ala-Seppälä, Ismo Mattila, Jonathan P Coles, Janek Frantzén, Peter J Hutchinson, Ari J Katila, Anna Kyllönen, Henna-Riikka Maanpää, Virginia Newcombe, Joanne Outtrim, Jussi Tallus, Keri LH Carpenter, David K Menon, Tuulia Hyötyläinen, Olli Tenovuo, Matej Orešic
Sep 27, 2018
Novel ketone diet enhances physical and cognitive performance.
Andrew J Murray, Nicholas S Knight, Mark A Cole, Lowri E Cochlin, Emma Carter, Kirill Tchabanenko, Tica Pichulik, Melanie K Gulston, Helen J Atherton, Marie A Schroeder, Robert MJ Deacon, Yoshihiro Kashiwaya, M Todd King, Robert Pawlosky, J Nicholas P Rawlins, Damian J Tyler, Julian L Griffin, Jeremy Robertson, Richard L Veech, Kieran Clarke
Sep 29, 2016
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.
Aldi T Kraja, Chunyu Liu, Jessica L Fetterman, Mariaelisa Graff, Christian Theil Have, Charles Gu, Lisa R Yanek, Mary F Feitosa, Dan E Arking, Daniel I Chasman, Kristin Young, Symen Ligthart, W David Hill, Stefan Weiss, Jian'an Luan, Franco Giulianini, Ruifang Li-Gao, Fernando P Hartwig, Shiow J Lin, Lihua Wang, Tom G Richardson, Jie Yao, Eliana P Fernandez, Mohsen Ghanbari, Mary K Wojczynski, Wen-Jane Lee, Maria Argos, Sebastian M Armasu, Ruteja A Barve, Kathleen A Ryan, Ping An, Thomas J Baranski, Suzette J Bielinski, Donald W Bowden, Ulrich Broeckel, Kaare Christensen, Audrey Y Chu, Janie Corley, Simon R Cox, Andre G Uitterlinden, Fernando Rivadeneira, Cheryl D Cropp, E Warwick Daw, Diana van Heemst, Lisa de Las Fuentes, He Gao, Ioanna Tzoulaki, Tarunveer S Ahluwalia, Renée de Mutsert, Leslie S Emery, A Mesut Erzurumluoglu, James A Perry, Mao Fu, Nita G Forouhi, Zhenglong Gu, Yang Hai, Sarah E Harris, Gibran Hemani, Steven C Hunt, Marguerite R Irvin, Anna E Jonsson, Anne E Justice, Nicola D Kerrison, Nicholas B Larson, Keng-Hung Lin, Latisha D Love-Gregory, Rasika A Mathias, Joseph H Lee, Matthias Nauck, Raymond Noordam, Ken K Ong, James Pankow, Amit Patki, Alison Pattie, Astrid Petersmann, Qibin Qi, Rasmus Ribel-Madsen, Rebecca Rohde, Kevin Sandow, Theresia M Schnurr, Tamar Sofer, John M Starr, Adele M Taylor, Alexander Teumer, Nicholas J Timpson, Hugoline G de Haan, Yujie Wang, Peter E Weeke, Christine Williams, Hongsheng Wu, Wei Yang, Donglin Zeng, Daniel R Witte, Bruce S Weir, Nicholas J Wareham, Henrik Vestergaard, Stephen T Turner, Christian Torp-Pedersen, Evie Stergiakouli, Wayne Huey-Herng Sheu, Frits R Rosendaal, M Arfan Ikram, Oscar H Franco, Paul M Ridker, Thomas T Perls, Oluf Pedersen, Ellen A Nohr, Anne B Newman, Allan Linneberg, Claudia Langenberg, Tuomas O Kilpeläinen, Sharon LR Kardia, Marit E Jørgensen, Torben Jørgensen, Thorkild IA Sørensen, Georg Homuth, Torben Hansen, Mark O Goodarzi, Ian J Deary, Cramer Christensen, Yii-Der Ida Chen, Aravinda Chakravarti, Ivan Brandslund, Klaus Bonnelykke, Kent D Taylor, James G Wilson, Santiago Rodriguez, Gail Davies, Bernardo L Horta, Bharat Thyagarajan, DC Rao, Niels Grarup, Victor G Davila-Roman, Gavin Hudson, Xiuqing Guo, Donna K Arnett, Caroline Hayward, Dhananjay Vaidya, Dennis O Mook-Kanamori, Hemant K Tiwari, Daniel Levy, Ruth JF Loos, Abbas Dehghan, Paul Elliott, Afshan N Malik, Robert A Scott, Diane M Becker, Mariza de Andrade, Michael A Province, James B Meigs, Jerome I Rotter, Kari E North
Feb 07, 2019
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the CHARGEmtDNA+ Consortium, we studied genetic...
BMI HOMA-B HOMA-IR HbA1c MT-nDNA candidate genes Glucose Insulin Mitochondria mtDNA waist-to-hip ratio Adipocytes Body Mass Index Cardiovascular Diseases Cohort Studies DNA Mitochondrial Diabetes mellitus Genes Mitochondrial genetic variation Glucose Glycated Hemoglobin Humans Insulin metabolism Mitochondria Quantitative Trait Loci Waist-Hip Ratio
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis.
Chenzhi Jing, Tomas Castro-Dopico, Nathan Richoz, Zewen K Tuong, John R Ferdinand, Laurence SC Lok, Kevin W Loudon, Gemma D Banham, Rebeccah J Mathews, Zaeem Cader, Susan Fitzpatrick, Kathleen R Bashant, Mariana J Kaplan, Arthur Kaser, Randall S Johnson, Michael P Murphy, Richard M Siegel, Menna R Clatworthy
May 20, 2020
IgG antibodies cause inflammation and organ damage in autoimmune diseases such as systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages isolated from inflamed tissues in immune complex...
Fcγ receptors Lupus Nephritis metabolism Animals Cells Cultured Cellular Reprogramming Dinoprostone Energy Metabolism Gene Expression Regulation Glycolysis Humans Immunoglobulin G Interleukin-1beta Kidney Lupus Nephritis MACROPHAGES Mice Mice Inbred C57BL Mice Knockout Reactive Oxygen Species Receptors IgG
A cross-platform approach identifies genetic regulators of human metabolism and health.
Luca A Lotta, Maik Pietzner, Isobel D Stewart, Laura BL Wittemans, Chen Li, Roberto Bonelli, Johannes Raffler, Emma K Biggs, Clare Oliver-Williams, Victoria PW Auyeung, Jian'an Luan, Eleanor Wheeler, Ellie Paige, Praveen Surendran, Gregory A Michelotti, Robert A Scott, Stephen Burgess, Verena Zuber, Eleanor Sanderson, Albert Koulman, Fumiaki Imamura, Nita G Forouhi, Kay-Tee Khaw, MacTel Consortium, Julian L Griffin, Angela M Wood, Gabi Kastenmüller, John Danesh, Adam S Butterworth, Fiona M Gribble, Frank Reimann, Melanie Bahlo, Eric Fauman, Nicholas J Wareham, Claudia Langenberg
Jan 12, 2021
In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10-10) characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and enrichment for nonsynonymous variation. We...
Diabetes mellitus Type 2 Eye Diseases Gene Frequency Genetic Loci Genetic Pleiotropy Genome Human Glucagon-Like Peptide-2 Receptor Glycine HEALTH Humans Linear Models Mendelian Randomization Analysis metabolism metabolism Inborn Errors Metabolome Mutation Missense Phenotype Polymorphism Single Nucleotide Retinal Telangiectasis Sample Size Serine
High-depth African genomes inform human migration and health.
Ananyo Choudhury, Shaun Aron, Laura R Botigué, Dhriti Sengupta, Gerrit Botha, Taoufik Bensellak, Gordon Wells, Judit Kumuthini, Daniel Shriner, Yasmina J Fakim, Anisah W Ghoorah, Eileen Dareng, Trust Odia, Oluwadamilare Falola, Ezekiel Adebiyi, Scott Hazelhurst, Gaston Mazandu, Oscar A Nyangiri, Mamana Mbiyavanga, Alia Benkahla, Samar K Kassim, Nicola Mulder, Sally N Adebamowo, Emile R Chimusa, Donna Muzny, Ginger Metcalf, Richard A Gibbs, TrypanoGEN Research Group, Charles Rotimi, Michèle Ramsay, H3Africa Consortium, Adebowale A Adeyemo, Zané Lombard, Neil A Hanchard
Dec 24, 2020
The African continent is regarded as the cradle of modern humans and African genomes contain more genetic variation than those from any other continent, yet only a fraction of the genetic diversity among African individuals has...
The genotypic and phenotypic spectrum of MTO1 deficiency.
James J O'Byrne, Maja Tarailo-Graovac, Aisha Ghani, Michael Champion, Charu Deshpande, Ali Dursun, Riza K Ozgul, Peter Freisinger, Ian Garber, Tobias B Haack, Rita Horvath, Ivo Barić, Ralf A Husain, Leo AJ Kluijtmans, Urania Kotzaeridou, Andrew A Morris, Colin J Ross, Saikat Santra, Jan Smeitink, Mark Tarnopolsky, Saskia B Wortmann, Johannes A Mayr, Michaela Brunner-Krainz, Holger Prokisch, Wyeth W Wasserman, Ron A Wevers, Udo F Engelke, Richard J Rodenburg, Teck Wah Ting, Robert McFarland, Robert W Taylor, Ramona Salvarinova, Clara DM van Karnebeek
Mar 07, 2019
BACKGROUND: Mitochondrial diseases, a group of multi-systemic disorders often characterized by tissue-specific phenotypes, are usually progressive and fatal disorders resulting from defects in oxidative phosphorylation. MTO1...
Cardiomyopathy ketogenic diet lactic acidosis mitochondrial disease Mitochondrial translation optimization 1 Oxidative Phosphorylation Defect Adolescent Biopsy Brain Cardiomyopathy Hypertrophic Carrier Proteins Child Child Preschool Female Frameshift Mutation Hepatic encephalopathy Humans Infant Infant Newborn Male metabolism Inborn Errors Mitochondrial Diseases Oxidative Phosphorylation RNA-Binding Proteins