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Control of mitochondrial superoxide production by reverse electron transport at complex I.
Ellen L Robb, Andrew R Hall, Tracy A Prime, Simon Eaton, Marten Szibor, Carlo Viscomi, Andrew M James, Michael P Murphy
Dec 17, 2018
The generation of mitochondrial superoxide (O2̇̄) by reverse electron transport (RET) at complex I causes oxidative damage in pathologies such as ischemia reperfusion injury, but also provides the precursor to H2O2 production in...
RET coenzyme Q Complex I Mitochondria mitochondrial membrane potential reactive oxygen species (ROS) redox signaling Respiration reverse electron transport Superoxide Animals Electron Transport Electron Transport Complex I Female Hydrogen Peroxide Male Mice Mice Inbred C57BL Mitochondria Heart Oxidative Phosphorylation Rats Rats Wistar Signal Transduction Superoxides Ubiquinone